Ets Variant 6 (ETV6) (N-Term) antibody

Details for Product No. ABIN504653
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Antigen
Synonyms tel, id:ibd2308, etv-6, tel/abl, TEL, TEL/ABL, AW123102, AW557856, Tel
Epitope
N-Term
(13), (10), (7), (7), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Chicken, Zebrafish, Dog (Canine), Xenopus laevis
(67), (33), (13), (13), (13), (12), (1), (1), (1)
Host
Rabbit
(63), (11), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(66), (41), (15), (10), (10), (7), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN504653
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ETV6
Sequence WAENEFSLRP IDSNTFEMNG KALLLLTKED FRYRSPHSGD VLYELLQHIL
Cross-Reactivity Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 100 %, African clawed frog : 90 %, Guinea pig : 90 %
Purification Affinity Purified
Alternative Name ETV6 / TEL1
Background ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. it contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Molecular Weight 53 kDa
NCBI Accession NP_001978, NM_001987
UniProt P41212
Application Notes WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: 721_B cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 452 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Ets Variant 6 (ETV6) (N-Term) antibody WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 721_B cell lysate
Background publications Rubnitz, Wichlan, Devidas et al.: "Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 26, Issue 13, pp. 2186-91, 2008 (PubMed).

Validation Images
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