MEF2C antibody (Middle Region)

Catalog No. ABIN504660

Product Details anti-MEF2C Antibody

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio), Dog, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEF2C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPSALSQLGA CTSTHLSQSS NLSLPSTQSL NIKSEPVSPP RDRTTTPSRY

Cross-Reactivity: Dog (Canine), Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)

Predicted Reactivity: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MEF2C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MEF2C

Application Details

Application Notes: WB Suggested Anti-MEF2C Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: COLO205 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 473 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Alternative Name: MEF2C (MEF2C Products)

Synonyms: MEF2C antibody, XMEF2C antibody, si:ch211-202e12.2 antibody, C5DELq14.3 antibody, DEL5q14.3 antibody, 5430401D19Rik antibody, 9930028G15Rik antibody, AV011172 antibody, Mef2 antibody, RGD1563119 antibody, id:ibd5026 antibody, mef2c antibody, wu:fc05b06 antibody, zgc:64184 antibody, zgc:85726 antibody, myocyte enhancer factor 2C antibody, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) antibody, myocyte enhancer factor 2cb antibody, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog antibody, myocyte enhancer factor 2ca antibody, MEF2C antibody, mef2c antibody, mef2cb antibody, mef2c.L antibody, Mef2c antibody, mef2ca antibody

Background: MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. MEF2C may also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Alias Symbols: C5DELq14.3, DEL5q14.3
Protein Interaction Partner: PLA2G12A, UBC, ASCL1, SUMO1, HDAC7, HDAC5, HDAC4, MYOD1, IFRD1, NCOA2, SIRT1, HDAC9, COPS5, YWHAZ, SPTBN1, MAPK7, EPAS1, MAPK14, VGLL2, VGLL4, TWIST2, GATA4, SOX18, EP300, SMAD2, MEF2D, MEF2C, NOTCH1, TEAD1, SP1, CCNB1, CDK1, CSNK2A1, MYOG,
Protein Size: 473

Molecular Weight: 51 kDa

Gene ID: 4208

NCBI Accession: NM_002397, NP_002388

UniProt: Q06413

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling