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Retinoic Acid Receptor, alpha (RARA) (Middle Region) antibody

Details for Product No. ABIN504661
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Antigen
Synonyms RAR, NR1B1, Nr1b1, RARalpha1, nr1b1, rara2a, RAR-ALPHA1, HS-RARa, rar-alpha
Epitope
Middle Region
(16), (16), (12), (11), (7), (7), (7), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Chicken, Xenopus laevis
(107), (55), (48), (7), (7), (1), (1), (1), (1)
Host
Rabbit
(74), (34), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(106), (70), (36), (27), (19), (10), (10), (8), (6), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN504661
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the middle region of human RARA
Sequence EMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPS SNRSSPATHS
Cross-Reactivity Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Rabbit : 100 %, Chicken : 90 %, Mouse : 80 %, Rat : 80 %, African clawed frog : 70 %
Purification Affinity Purified
Alternative Name RAR-alpha / RARA
Background Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Molecular Weight 51 kDa
NCBI Accession NM_000964, NP_000955
UniProt P10276
Application Notes WB Suggested Anti-RARA Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: OVCAR-3 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 462 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Retinoic Acid Receptor, alpha (RARA) (Middle Region) antibody WB Suggested Anti-RARA Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: OVCAR-3 cell lysate
Background publications Garapaty, Mahajan, Samuels: "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 6806-16, 2008 (PubMed).

Hosts (74), (34), (7)
Reactivities (107), (55), (48), (7), (7), (1), (1), (1), (1)
Applications (106), (70), (36), (27), (19), (10), (10), (8), (6), (1), (1), (1), (1)
Conjugates (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (16), (12), (11), (7), (7), (7), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN504661
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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