anti-Retinoic Acid Receptor alpha antibody (Retinoic Acid Receptor, alpha) (Middle Region)

Details for Product anti-RARA Antibody No. ABIN504661
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Antigen
Synonyms rar-alpha, nr1b1, NR1B1, RAR, Nr1b1, RARalpha1, HS-RARa, rara2a, RAR-ALPHA1
Epitope
Middle Region
(36), (18), (17), (15), (12), (10), (9), (8), (6), (5), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(154), (66), (58), (7), (6), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(109), (41), (18)
Clonality
Polyclonal
Conjugate
This Retinoic Acid Receptor alpha antibody is un-conjugated
(6), (6), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(148), (89), (65), (26), (24), (18), (11), (10), (5), (3), (2), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human RARA
Sequence EMLENSEGLD TLSGQPGGGG RDGGGLAPPP GSCSPSLSPS SNRSSPATHS
Cross-Reactivity Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Rabbit : 100 %, Chicken : 90 %, Mouse : 80 %, Rat : 80 %, African clawed frog : 70 %
Purification Affinity Purified
Alternative Name RAR-alpha / RARA (RARA Antibody Abstract)
Background Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Molecular Weight 51 kDa
NCBI Accession NP_000955, NM_000964
UniProt P10276
Application Notes WB Suggested Anti-RARA Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: OVCAR-3 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 462 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Retinoic Acid Receptor, alpha (RARA) (Middle Region) antibody WB Suggested Anti-RARA Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Garapaty, Mahajan, Samuels: "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 6806-16, 2008 (PubMed).

Validation Images
Catalog No. ABIN504661
289.00 $
Plus shipping costs $45.00
Quantity
Price
50 μg
289.00 $

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