FBXW7 antibody (AA 1-627)

Catalog No. ABIN527477

Product Details anti-FBXW7 Antibody

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Binding Specificity: AA 1-627

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Mouse polyclonal antibody raised against a full-length human FBXW7 protein.

Sequence: MCVPRSGLIL SCICLYCGVL LPVLLPNLPF LTCLSMSTLE SVTYLPEKGL YCQRLPSSRT HGGTESLKGK NTENMGFYGT LKMIFYKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: FBXW7 (NP_060785.2, 1 a.a. ~ 627 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-FBXW7 antibody (ABIN527477)

Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: "Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length." in: The EMBO journal, Vol. 34, Issue 19, pp. 2424-40, (2015) (PubMed).

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7 (FBXW7 Products)

Background: Full Gene Name: F-box and WD repeat domain containing 7
Synonyms: AGO,CDC4,DKFZp686F23254,FBW6,FBW7,FBX30,FBXO30,FBXW6,FLJ16457,SEL-10,SEL10

Gene ID: 55294

NCBI Accession: NM_018315

Pathways: Notch Signaling, EGFR Signaling Pathway