TNFRSF10A antibody (PE)

Catalog No. ABIN536642

Product Details anti-TNFRSF10A Antibody (PE)

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against partial recombinant TNFRSF10A.

Specificity: This antibody recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived.

Cross-Reactivity: Human

Immunogen: Recombinant Fc fusion protein corresponding to extracellular region of TNFRSF10A.

Clone: DR-4-02

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (5 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-TNFRSF10A antibody (PE) (ABIN536642)

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Corallini, Milani, Nicolin, Secchiero: "TRAIL, caspases and maturation of normal and leukemic myeloid precursors." in: Leukemia & lymphoma, Vol. 47, Issue 8, pp. 1459-68, (2006) (PubMed).

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: CD261 / TRAILR1 (TNFRSF10A Products)

Synonyms: APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNFRSF10A antibody, TNF receptor superfamily member 10a antibody, tumor necrosis factor receptor superfamily member 26 antibody, tumor necrosis factor receptor superfamily, member 10a antibody, TNFRSF10A antibody, LOC510798 antibody

Gene ID: 8797

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity