PUMA antibody

Catalog No. ABIN540857

Product Details anti-PUMA Antibody

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PUMA antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of BBC3.

Sequence: EQHLESPVPS APGALAG

Specificity: Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide corresponding to exon-3-encoded region of human BBC3.

Application Details

Application Notes: Western Blot (1:500-1:1)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-PUMA antibody (ABIN540857)

Stylianou, Clarke, Brennan: "Aberrant activation of notch signaling in human breast cancer." in: Cancer research, Vol. 66, Issue 3, pp. 1517-25, (2006) (PubMed).

Nakano, Vousden: "PUMA, a novel proapoptotic gene, is induced by p53." in: Molecular cell, Vol. 7, Issue 3, pp. 683-94, (2001) (PubMed).

Target Details for PUMA

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Alternative Name: PUMA (BBC3 Products)

Synonyms: BBC3 antibody, Puma antibody, JFY-1 antibody, JFY1 antibody, PUMA antibody, PUMA/JFY1 antibody, BCL2 binding component 3 antibody, Bcl-2 binding component 3 antibody, BBC3 antibody, Bbc3 antibody, bbc3 antibody

Gene ID: 27113

Pathways: p53 Signaling, Positive Regulation of Endopeptidase Activity