X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (AA 1-109) antibody

Details for Product No. ABIN550603
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Antigen
Synonyms zgc:73312, MGC81443, homolog of human DNA ligase iv-binding protein XRCC4, 2310057B22Rik, AW413319, AW545101
Epitope
AA 1-109
(7), (7), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(71), (19), (17), (13), (12), (12)
Host
Rabbit
(61), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(59), (18), (15), (11), (10), (6), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN550603
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 109 of XRCC4
Isotype IgG
Predicted Reactivity Bovine (82%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name XRCC4
Background The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq]
Synonyms: XRCC4 antibody, X-ray repair cross-complementing protein 4 antibody, DNA repair protein XRCC4 antibody, "X-ray repair, complementing defective, repair in Chinese hamster antibody", X-ray repair complementing defective repair in Chinese hamster cells 4 antibody
Molecular Weight 38 kDa
UniProt Q13426
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Comment

Positive Controls: A431 , HeLa

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Liu, Li, Widlak et al.: "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8461-6, 1998 (PubMed).

Mukae, Enari, Sakahira et al.: "Molecular cloning and characterization of human caspase-activated DNase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 16, pp. 9123-8, 1998 (PubMed).

Liu, Zou, Widlak et al.: "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13836-40, 1999 (PubMed).

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