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Glutathione S-Transferase mu 1 (GSTM1) (AA 158-168) antibody

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AA 158-168
(34), (20), (7), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(104), (24), (20), (8), (4), (3), (1), (1), (1), (1)
(85), (29), (17), (1)
(10), (8), (3), (3), (3), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(105), (78), (27), (19), (14), (10), (8), (3), (3), (2), (2)
Pubmed 4 references available
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Quantity 0.1 mL
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Immunogen Synthetic peptide contain a sequence corresponding to a region within amino acids 158 and 168 of GSTM1
Isotype IgG
Predicted Reactivity Bovine (91%)
Characteristics Cellular Localization: Cytoplasm
Purification Purified by antigen-affinity chromatography..
Alternative Name GSTM1 (GSTM1 Antibody Abstract)
Background Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual&apos,s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]
Synonyms: GST1 antibody, GSTM1-1 antibody, GSTM1a-1a antibody, GSTM1b-1b antibody, GTH4 antibody, GTM1 antibody, H-B antibody, MGC26563 antibody, MU antibody, MU-1 antibody, GSTM1 antibody, HB subunit 4 antibody, glutathione S-aralkyltransferase antibody, glutathione S-transferase M1 antibody, S-(hydroxyalkyl)glutathione lyase antibody, glutathione S-aryltransferase antibody, GST class-mu 1 antibody, GST HB subunit 4 antibody, glutathione S-alkyltransferase antibody, glutathione S-transferase Mu 1 antibody
Molecular Weight 26 kDa
Research Area Signaling, Metabolism, Enzymes

Positive Controls: HeLa

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-Glutathione S-Transferase mu 1 (GSTM1) (AA 158-168) antibody (ABIN550736) anti-Glutathione S-Transferase mu 1 (GSTM1) (AA 158-168) antibody
Western Blotting (WB) image for anti-Glutathione S-Transferase mu 1 (GSTM1) (AA 158-168) antibody (ABIN550736) anti-Glutathione S-Transferase mu 1 (GSTM1) (AA 158-168) antibody (Image 2)
Background publications Sakahira, Enari, Nagata: "Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15740-4, 1999 (PubMed).

Sakahira, Enari, Nagata: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, 1998 (PubMed).

Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Liu, Zou, Slaughter et al.: "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis." in: Cell, Vol. 89, Issue 2, pp. 175-84, 1997 (PubMed).

Catalog No. ABIN550736

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