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HNF4A antibody (Hepatocyte Nuclear Factor 4, alpha) (AA 1-45)

Details for Product anti-HNF4A Antibody No. ABIN550747, Supplier: Login to see New
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AA 1-45
(25), (19), (13), (13), (10), (8), (7), (7), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(174), (53), (47), (10), (7), (6), (4), (1), (1), (1), (1), (1), (1)
(133), (27), (20)
This HNF4A antibody is un-conjugated
(4), (4), (3), (3), (3), (3), (3)
Western Blotting (WB)
(163), (82), (37), (27), (19), (9), (5), (4), (4), (3), (3), (2), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mL
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to a region within amino acids 1 and 45 of HNF4 alpha
Isotype IgG
Predicted Reactivity Mouse (86%), Rat (93%), Xenopus laevis (86%), Pig (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name HNF4 alpha / TCF14 (HNF4A Antibody Abstract)
Background The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
Synonyms: FLJ39654 antibody, HNF4 antibody, HNF4a7 antibody, HNF4a8 antibody, HNF4a9 antibody, HNF4alpha antibody, MODY antibody, MODY1 antibody, NR2A1 antibody, NR2A21 antibody, TCF antibody, TCF14 antibody, HNF4A antibody, hepatic nuclear factor 4 alpha antibody, HNF4alpha10/11/12 antibody, TCF-14 antibody, transcription factor 14 antibody, hepatocyte nuclear factor 4-alpha antibody, nuclear receptor subfamily 2 group A member 1 antibody, transcription factor HNF-4 antibody, HNF-4-alpha antibody, transcription factor-14 antibody, "hepatocyte nuclear factor 4, alpha antibody"
Molecular Weight 53 kDa
UniProt P41235
Pathways AMPK Signaling, Nuclear Receptor Transcription Pathway

Positive Controls: A431 , H1299 , HeLa , HepG2

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Western Blotting (WB) image for anti-HNF4A antibody (Hepatocyte Nuclear Factor 4, alpha) (AA 1-45) (ABIN550747) anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 1-45) antibody
Product cited in: Ferrigno, Silver: "Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival." in: Oncogene, Vol. 18, Issue 45, pp. 6129-34, 1999 (PubMed).

Background publications Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Catalog No. ABIN550747

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