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Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 1-45) antibody

Details for Product No. ABIN550747
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Antigen
Synonyms
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF1 ... show more
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF14, HNF-4alpha, fb58h09, id:ibd1279, wu:fb58h09, hnf4, nr2a1 show less
Epitope
AA 1-45
(22), (18), (10), (10), (8), (6), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(126), (60), (59), (28), (26), (25), (24), (4), (1), (1)
Host
Rabbit
(104), (20), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(110), (56), (25), (22), (20), (15), (13), (4), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN550747
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Immunogen Synthetic peptide corresponding to a region within amino acids 1 and 45 of HNF4 alpha
Isotype IgG
Predicted Reactivity Mouse (86%), Rat (93%), Xenopus laevis (86%), Pig (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name HNF4 alpha / TCF14
Background The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
Synonyms: FLJ39654 antibody, HNF4 antibody, HNF4a7 antibody, HNF4a8 antibody, HNF4a9 antibody, HNF4alpha antibody, MODY antibody, MODY1 antibody, NR2A1 antibody, NR2A21 antibody, TCF antibody, TCF14 antibody, HNF4A antibody, hepatic nuclear factor 4 alpha antibody, HNF4alpha10/11/12 antibody, TCF-14 antibody, transcription factor 14 antibody, hepatocyte nuclear factor 4-alpha antibody, nuclear receptor subfamily 2 group A member 1 antibody, transcription factor HNF-4 antibody, HNF-4-alpha antibody, transcription factor-14 antibody, "hepatocyte nuclear factor 4, alpha antibody"
Molecular Weight 53 kDa
UniProt P41235
Comment

Positive Controls: A431 , H1299 , HeLa , HepG2

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

Ferrigno, Silver: "Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival." in: Oncogene, Vol. 18, Issue 45, pp. 6129-34, 1999 (PubMed).

Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

Validation Images
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