Interleukin 23 (IL23) antibody

Details for Product No. ABIN5507484, Supplier: Log in to see
Antigen
  • FIL1
  • FIL1(ZETA)
  • FIL1Z
  • IL-1F7
  • IL-1H
  • IL-1H4
  • IL-1RP1
  • IL-37
  • IL1F7
  • IL1H4
  • IL1RP1
  • interleukin 37
  • IL37
Reactivity
Human
55
39
19
1
1
Host
Mouse
50
17
3
1
Antibody Type
Recombinant Antibody
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Neutralization (Neut)
36
19
13
12
9
7
6
5
3
2
1
1
1
1
1
Options
Supplier
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Immunogen Recombinant Human IL23A & Mouse IL12B Heterodimer Protein (ABIN2215796)
Clone Mh066
Isotype IgG1
Specificity Human IL23A & Human IL12B Heterodimer
Has cross-reactivity with with Cynomolgus IL-23 & IL12B Heterodimer Protein (Catalog # CT037-C08H ) in ELISA assay
No cross-reactivity with Mouse IL-23 & IL12B Heterodimer (Catalog # CT028-M08H) and Rat IL-23 & IL12B Heterodimer Protein (Catalog # CT045-R08H) in ELISA assay
Cross-Reactivity Cynomolgus
No Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Human IL23A & Mouse IL12B Heterodimer. The antibody was produced using recombinant antibody technology.
Endotoxin Level < 3 EU/mg
Alternative Name IL23 (IL23 Antibody Abstract)
Application Notes In a functional ELISA which immobilized recombinant Human IL23R/Fc Chimera (Catalog # 13840-H02H) at 8 μg/mL (100 μL/well) in the plate, the Rabbit anti-Human IL23a Monoclonal Antibody (Catalog # CT012-M066) can block the binding of 0.5 μg/mL of biotinylated recombinant Human IL23A & Human IL12B Heterodimer Protein (Catalog # CT012-H08H) to human IL23R, the EC50 is 0.59 μg/mL.
The neutralization activity of antibody is Measured by its ability to neutralize IL23-induced IL17A secretion in mouse splenocytes. The Neutralization titer (IC50) is typically 10.0-15.0 ng/mL in the presence of 10 ng/mL Recombinant Human IL-23 (CT048-H08H) and ConA (1 μg/mL ) .
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in Histidine and Arginine buffer containing 120 mM NaCl, 0.02 % Tween 80, pH 6.0
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
Supplier Images
 image for anti-Interleukin 23 (IL23) antibody (ABIN5507484) IL17a secretion in the mouse splenocytes induced by 10 ng/mL of Recombinant Human IL2...
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