Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody

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Antigen
Epitope
AA 1-93
(16), (7), (6), (4), (4), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(91), (33), (29), (4), (4), (3), (3), (1), (1), (1), (1)
Host
Rabbit
(65), (19), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(77), (33), (32), (19), (11), (9), (5), (4), (3), (1)
Pubmed 5 references available
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Quantity 0.1 mL
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Immunogen Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 93 of ACADM
Isotype IgG
Predicted Reactivity Mouse (81%), Pig (83%), Bovine (88%)
Characteristics Cellular Localization: Mitochondrion matrix
Purification Purified by antigen-affinity chromatography..
Alternative Name ACADM (ACADM Antibody Abstract)
Background This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: ACAD1 antibody, FLJ18227 antibody, FLJ93013 antibody, FLJ99884 antibody, MCAD antibody, MCADH antibody, ACADM antibody, "acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain antibody", "medium-chain specific acyl-CoA dehydrogenase, mitochondrial antibody", "acyl-CoA dehydrogenase, C-4 to C-12 straight chain antibody"
Molecular Weight 47 kDa
UniProt P11310
Research Area Cancer, Metabolism
Comment

Positive Controls: 293T , A431 , HeLa , HepG2 , Raji

Restrictions For Research Use only
Format Liquid
Concentration 0.74 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody (ABIN550859) anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody
Indirect Immunofluorescence Assay (IFA) image for anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody (ABIN550859) anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody (Image 2)
Western Blotting (WB) image for anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody (ABIN550859) anti-Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody (Image 3)
Product cited in: Wissing, Mouritzen, Jäättelä: "TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20." in: Free radical biology & medicine, Vol. 25, Issue 1, pp. 57-65, 1999 (PubMed).

Tewari, Wolf, Seldin et al.: "Lymphoid expression and regulation of A20, an inhibitor of programmed cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1699-706, 1995 (PubMed).

Dixit, Green, Sarma et al.: "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin." in: The Journal of biological chemistry, Vol. 265, Issue 5, pp. 2973-8, 1990 (PubMed).

Background publications Heyninck, De Valck, Vanden Berghe et al.: "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN." in: The Journal of cell biology, Vol. 145, Issue 7, pp. 1471-82, 1999 (PubMed).

Opipari, Boguski, Dixit: "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein." in: The Journal of biological chemistry, Vol. 265, Issue 25, pp. 14705-8, 1990 (PubMed).

Catalog No. ABIN550859
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