Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) (AA 1-93) antibody

Details for Product No. ABIN550859
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms acaDM, ACAD1, MCAD, MCADH, AU018656
Epitope
AA 1-93
(6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(61), (30), (26), (15), (14), (14), (12), (2), (1)
Host
Rabbit
(50), (7), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(50), (20), (15), (14), (12), (10), (6), (4), (4), (4)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN550859
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 93 of ACADM
Isotype IgG
Predicted Reactivity Mouse (81%), Pig (83%), Bovine (88%)
Characteristics Cellular Localization: Mitochondrion matrix
Purification Purified by antigen-affinity chromatography..
Alternative Name ACADM
Background This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: ACAD1 antibody, FLJ18227 antibody, FLJ93013 antibody, FLJ99884 antibody, MCAD antibody, MCADH antibody, ACADM antibody, "acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain antibody", "medium-chain specific acyl-CoA dehydrogenase, mitochondrial antibody", "acyl-CoA dehydrogenase, C-4 to C-12 straight chain antibody"
Molecular Weight 47 kDa
UniProt P11310
Research Area Cancer, Metabolism
Comment

Positive Controls: 293T , A431 , HeLa , HepG2 , Raji

Restrictions For Research Use only
Format Liquid
Concentration 0.74 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Opipari, Boguski, Dixit: "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein." in: The Journal of biological chemistry, Vol. 265, Issue 25, pp. 14705-8, 1990 (PubMed).

Dixit, Green, Sarma et al.: "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin." in: The Journal of biological chemistry, Vol. 265, Issue 5, pp. 2973-8, 1990 (PubMed).

Tewari, Wolf, Seldin et al.: "Lymphoid expression and regulation of A20, an inhibitor of programmed cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1699-706, 1995 (PubMed).

Wissing, Mouritzen, Jäättelä: "TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20." in: Free radical biology & medicine, Vol. 25, Issue 1, pp. 57-65, 1999 (PubMed).

Heyninck, De Valck, Vanden Berghe et al.: "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN." in: The Journal of cell biology, Vol. 145, Issue 7, pp. 1471-82, 1999 (PubMed).

Validation Images
Did you look for something else?
back to top