Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) (AA 1-74) antibody

Details for Product No. ABIN550944
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Antigen
Synonyms mmp-9, fgMMP-9, mmp9, AW743869, B/MMP9, Clg4b, MMP-9, pro-MMP-9, CLG4B, GELB, MANDP2, clg4b, gelb, mandp2, ZFMMP-9, wu:fb02g06, wu:fb07b05, wu:fi98c09, wu:fj05a08, zgc:64165
Epitope
AA 1-74
(39), (23), (14), (13), (8), (7), (6), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(287), (100), (69), (36), (36), (19), (14), (12), (4), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(220), (110), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(15), (10), (9), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(233), (100), (87), (87), (63), (38), (35), (24), (21), (15), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN550944
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Immunogen Synthetic peptide corresponding to a region within amino acids 1 and 74 of MMP9
Isotype IgG
Predicted Reactivity Human (100%), Dog (93%), Pig (93%), Rabbit (86%), Rhesus Monkey (93%)
Characteristics Cellular Localization: Secreted , extracellular space , extracellular matrix
Purification Purified by antigen-affinity chromatography..
Alternative Name MMP-9
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq]
Synonyms: CLG4B antibody, GELB antibody, MANDP2 antibody, MMP-9 antibody, MMP9 antibody, "matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody", macrophage gelatinase antibody, matrix metalloproteinase-9 antibody, 92 kDa gelatinase antibody, 92 kDa type IV collagenase antibody, type V collagenase antibody, "matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody"
Molecular Weight 78 kDa
UniProt P14780
Research Area Extracellular Matrix
Comment

Positive Controls: Synthetic peptide: 1:8,000

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Hershko, Ciechanover: "The ubiquitin system." in: Annual review of biochemistry, Vol. 67, pp. 425-79, 1998 (PubMed).

Chen, Smith, Accavitti-Loper et al.: "Ubiquitylation and destruction of endogenous c-mycS by the proteasome: are myc boxes dispensable?" in: Archives of biochemistry and biophysics, Vol. 374, Issue 2, pp. 306-12, 2000 (PubMed).

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