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Coagulation Factor II (thrombin) (F2) (AA 363-619) antibody

Details for Product No. ABIN551242
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Antigen
Synonyms zgc:66319, wu:fb57c10, wu:fd42e09, wu:fd59d01, Cf-2, Cf2, FII, thrombin, PT, RPRGL2, THPH1, prothrombin, AA959438, AI255193, AI327365, C1sa, HTRA, HTRA1, F2
Epitope
AA 363-619
(6), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(94), (49), (23), (14), (13), (8), (3), (1), (1), (1)
Host
Rabbit
(67), (31), (27), (6), (5), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(27), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(78), (54), (18), (17), (14), (14), (13), (12), (10), (10), (7), (5), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551242
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Immunogen Recombinant fragment corresponding to a region within amino acids 363 and 619 of Thrombin
Isotype IgG
Characteristics Cellular Localization: Secreted , extracellular space
Purification Purified by antigen-affinity chromatography..
Alternative Name Thrombin
Background Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq]
Synonyms: PT antibody, F2 antibody, prothrombin antibody, serine protease antibody, prothrombin B-chain antibody, coagulation factor II (thrombin) antibody
Molecular Weight 70 kDa
UniProt P00734
Research Area Signaling, Extracellular Matrix, Apoptosis/Necrosis, Coagulation
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Muzio, Chinnaiyan, Kischkel et al.: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

Cock, Tepper, de Vries et al.: "CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase." in: The Journal of biological chemistry, Vol. 273, Issue 13, pp. 7560-5, 1998 (PubMed).

Boesen-de Cock, Tepper, de Vries et al.: "Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 14255-61, 1999 (PubMed).

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