Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 311-509) antibody

Details for Product No. ABIN551244
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Antigen
Synonyms zgc:136695, LCK, Hck-3, Lsk, Lskt, p56, p56Lck, LSK, YT16, p56lck, pp58lck, P56LCK, tkl, Lck1, Lcktkr
Epitope
AA 311-509
(36), (30), (25), (19), (10), (10), (9), (9), (7), (7), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(269), (149), (126), (20), (18), (13), (13)
Host
Rabbit
(219), (56), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(242), (109), (47), (38), (34), (33), (23), (21), (17), (8), (7), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551244
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Immunogen Recombinant fragment corresponding to a region within amino acids 311 and 509 of Lck
Isotype IgG
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Pig (96%), Rat (97%), Zebrafish (85%), Bovine (97%)
Characteristics Cellular Localization: Cytoplasm , Cell membrane, Lipid-anchor, Cytoplasmic side
Purification Purified by antigen-affinity chromatography..
Alternative Name LCK
Background This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq]
Synonyms: LSK antibody, YT16 antibody, p56lck antibody, pp58lck antibody, LCK antibody, t cell-specific protein-tyrosine kinase antibody, tyrosine-protein kinase Lck antibody, p56(LSTRA) protein-tyrosine kinase antibody, proto-oncogene tyrosine-protein kinase LCK antibody, leukocyte C-terminal Src kinase antibody, T-lymphocyte specific protein tyrosine kinase p56lck antibody, lymphocyte cell-specific protein-tyrosine kinase antibody, lymphocyte-specific protein tyrosine kinase antibody
Molecular Weight 58 kDa
UniProt P06239
Research Area Signaling
Comment

Positive Controls: H1299 , NIH-3T3

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Muzio, Chinnaiyan, Kischkel et al.: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

Cock, Tepper, de Vries et al.: "CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase." in: The Journal of biological chemistry, Vol. 273, Issue 13, pp. 7560-5, 1998 (PubMed).

Fearnhead, Rodriguez, Govek et al.: "Oncogene-dependent apoptosis is mediated by caspase-9." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 23, pp. 13664-9, 1998 (PubMed).

Boesen-de Cock, Tepper, de Vries et al.: "Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 14255-61, 1999 (PubMed).

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