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High-Mobility Group Box 1 (HMGB1) (AA 1-159) antibody

Details for Product No. ABIN551245
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Antigen
Synonyms hmgb1, amphoterin, hmg-1, hmg1, hmg3, sbp-1, HMGB1, HMG1, HMG3, SBP-1, DEF, HMG-1, Hmg1, p30, Ac2-008, ik:tdsubc_1a5, wu:fb23c02, xx:tdsubc_1a5, zgc:56110, zgc:77104, Hmgb1
Epitope
AA 1-159
(23), (14), (14), (7), (6), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(181), (66), (62), (22), (12), (8), (5), (2), (2), (2), (1)
Host
Rabbit
(135), (62), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(178), (98), (51), (41), (33), (17), (16), (10), (9), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551245
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 159 of HMGB1
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Predicted Reactivity Dog (100%), Pig (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name HMGB1
Background DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
Synonyms: DKFZp686A04236 antibody, HMG1 antibody, HMG3 antibody, SBP-1 antibody, HMGB1 antibody, HMG-1 antibody, Amphoterin antibody, high-mobility group box 1 antibody, high mobility group protein B1 antibody, high mobility group protein 1 antibody, Sulfoglucuronyl carbohydrate binding protein antibody, high-mobility group (nonhistone chromosomal) protein 1 antibody
Molecular Weight 25 kDa
UniProt P09429
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Chromatin Binding Proteins, Neurology
Comment

Positive Controls: 293T , A431 , A375 , NIH-3T3 , JC , BCL-1 , C2C12 , Raw264.7 , PC-12

Restrictions For Research Use only
Format Liquid
Concentration 0.83 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Muzio, Chinnaiyan, Kischkel et al.: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

Cock, Tepper, de Vries et al.: "CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase." in: The Journal of biological chemistry, Vol. 273, Issue 13, pp. 7560-5, 1998 (PubMed).

Fearnhead, Rodriguez, Govek et al.: "Oncogene-dependent apoptosis is mediated by caspase-9." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 23, pp. 13664-9, 1998 (PubMed).

Boesen-de Cock, Tepper, de Vries et al.: "Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 14255-61, 1999 (PubMed).

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