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TEK Tyrosine Kinase, Endothelial (TEK) (AA 1-220) antibody

Details for Product No. ABIN551247
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Antigen
Synonyms TEK, DKFZp469E064, AA517024, Cd202b, Hyk, Tie2, tie-2, CD202B, TIE-2, TIE2, VMCM, VMCM1, Tie-2, tie2
Epitope
AA 1-220
(18), (17), (17), (16), (12), (11), (9), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(184), (122), (71), (66), (65), (48), (48), (1), (1)
Host
Rabbit
(133), (51), (24), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(19), (10), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(112), (92), (59), (54), (26), (24), (12), (8), (7), (5), (4), (4), (1), (1)
Pubmed 6 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551247
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 220 of TIE2
Isotype IgG
Predicted Reactivity Human (100%)
Purification Purified by antigen-affinity chromatography..
Alternative Name CD202b / TEK
Background The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]
Synonyms: CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, TEK antibody, p140 TEK antibody, hTIE2 antibody, tyrosine-protein kinase receptor TIE-2 antibody, tyrosine-protein kinase receptor TEK antibody, soluble TIE2 variant 1 antibody, angiopoietin-1 receptor antibody, soluble TIE2 variant 2 antibody, tunica interna endothelial cell kinase antibody, "TEK tyrosine kinase, endothelial antibody"
Molecular Weight 126 kDa
UniProt Q02763
Research Area CD Antigens, Surface Receptors of Immune Cells
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.13 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Duan, Chinnaiyan, Hudson et al.: "ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis." in: The Journal of biological chemistry, Vol. 271, Issue 3, pp. 1621-5, 1996 (PubMed).

Srinivasula, Fernandes-Alnemri, Zangrilli et al.: "The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32." in: The Journal of biological chemistry, Vol. 271, Issue 43, pp. 27099-106, 1996 (PubMed).

Thornberry, Rano, Peterson et al.: "A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 29, pp. 17907-11, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Li, Nijhawan, Budihardjo et al.: "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade." in: Cell, Vol. 91, Issue 4, pp. 479-89, 1997 (PubMed).

Wolf, Green: "Suicidal tendencies: apoptotic cell death by caspase family proteinases." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20049-52, 1999 (PubMed).

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