Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 1-179) antibody

Details for Product No. ABIN551388
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Antigen
Synonyms
fi20g03, pab-2, wu:fi20g03, zgc:55855, pab1, pabp, pabp1, pabpc2, PABPC1, pabpc1, wu:fb16a02, wu:fi19b08, wu:fj12d09, wu:fj61f06, zgc:109879, PAB1, PABP, PABP1, PABPC2, PABPL1, Pabp1, PabpI, Pabpl1, e ... show more
fi20g03, pab-2, wu:fi20g03, zgc:55855, pab1, pabp, pabp1, pabpc2, PABPC1, pabpc1, wu:fb16a02, wu:fi19b08, wu:fj12d09, wu:fj61f06, zgc:109879, PAB1, PABP, PABP1, PABPC2, PABPL1, Pabp1, PabpI, Pabpl1, ePAB, Pabp show less
Epitope
AA 1-179
(12), (12), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(41), (26), (22), (17), (13), (12), (12), (5), (4), (1)
Host
Rabbit
(34), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(34), (18), (15), (14), (10), (9), (6), (6), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN551388
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 179 of PABP
Isotype IgG
Cross-Reactivity Mouse (Murine), Squirrel
Predicted Reactivity Rat (100%), Xenopus Tropicalis (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
Characteristics Cellular Localization: Cytoplasm , Nucleus
Purification Affinity purified by Protein A..
Alternative Name PABPC1
Background The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4, MIM 603407), and PABP3 (PABPC3, MIM 604680). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.[supplied by OMIM]
Synonyms: PAB1 antibody, PABP antibody, PABP1 antibody, PABPC2 antibody, PABPL1 antibody, PABPC1 antibody, polyadenylate-binding protein 1 antibody, "poly(A) binding protein, cytoplasmic 2 antibody", "poly(A) binding protein, cytoplasmic 1 antibody"
Molecular Weight 71 kDa
UniProt P11940
Comment

Positive Controls: HepG2

Restrictions For Research Use only
Format Liquid
Concentration 5.95 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Sims, Giri, Dower: "The two interleukin-1 receptors play different roles in IL-1 actions." in: Clinical immunology and immunopathology, Vol. 72, Issue 1, pp. 9-14, 1994 (PubMed).

Sims, Painter, Gow: "Genomic organization of the type I and type II IL-1 receptors." in: Cytokine, Vol. 7, Issue 6, pp. 483-90, 1996 (PubMed).

Bernstein, Fay, Frankel et al.: "A phase I study of recombinant human soluble interleukin-1 receptor (rhu IL-1R) in patients with relapsed and refractory acute myeloid leukemia." in: Cancer chemotherapy and pharmacology, Vol. 43, Issue 2, pp. 141-4, 1999 (PubMed).

Born, Smith, Garka et al.: "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling." in: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 29946-54, 2000 (PubMed).

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