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Tryptophan Hydroxylase 1 antibody (TPH1) (AA 206-394)

Details for Product anti-TPH1 Antibody No. ABIN551429, Supplier: Login to see
Antigen
  • tph
  • tph1
  • tphD1
  • TPH
  • LOC100229598
  • TPRH
  • TRPH
  • Tph
  • SERGEF
Epitope
AA 206-394
26
25
20
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
130
81
55
42
10
7
7
6
5
4
3
3
1
Host
Rabbit
112
24
20
1
Clonality
Polyclonal
Conjugate
This Tryptophan Hydroxylase 1 antibody is un-conjugated
5
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
130
52
52
23
15
14
12
6
5
4
2
1
1
1
Supplier
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Immunogen Recombinant fragment contain a sequence corresponding to a region within amino acids 206 and 394 of Tryptophan Hydroxylase
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Human (100%)
Purification Purified by antigen-affinity chromatography..
Alternative Name Tryptophan 5-hydroxylase 1 (TPH1) (TPH1 Antibody Abstract)
Background This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Synonyms: MGC119994 antibody, TPRH antibody, TRPH antibody, TPH1 antibody, tryptophan hydroxylase (tryptophan 5-monooxygenase) antibody, tryptophan 5-monooxygenase 1 antibody, tryptophan 5-hydroxylase 1 antibody, L-tryptophan hydroxylase antibody, indoleacetic acid-5-hydroxylase antibody, tryptophan hydroxylase 1 antibody
Molecular Weight 51 kDa
UniProt P17752
Research Area Amino Acids, Enzymes, Metabolism
Pathways
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-Tryptophan Hydroxylase 1 antibody (TPH1) (AA 206-394) (ABIN551429) anti-Tryptophan Hydroxylase 1 (TPH1) (AA 206-394) antibody
Product cited in: Martinou, Green: "Breaking the mitochondrial barrier." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 1, pp. 63-7, 2001 (PubMed).

Joza, Susin, Daugas et al.: "Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death." in: Nature, Vol. 410, Issue 6828, pp. 549-54, 2001 (PubMed).

Background publications Susin, Lorenzo, Zamzami et al.: "Molecular characterization of mitochondrial apoptosis-inducing factor." in: Nature, Vol. 397, Issue 6718, pp. 441-6, 1999 (PubMed).