Notch 2 (NOTCH2) (AA 1669-1855) antibody

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Antigen
Synonyms AGS2, HJCYS, hN2, AI853703, N2, notch6, sb:cb884
Epitope
AA 1669-1855
(12), (9), (9), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(88), (50), (45), (14), (5), (3), (2), (1), (1)
Host
Rabbit
(83), (9), (6), (4), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
(63), (63), (25), (23), (18), (10), (8), (6), (5), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN551430
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Immunogen Recombinant fragment corresponding to a region within amino acids 1669 and 1855 of Notch 2
Isotype IgG
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Rat (89%)
Characteristics Cellular Localization: Cell membrane, Single-pass type I membrane protein , Notch 2 intracellular domain: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name NOTCH2
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq]
Synonyms: AGS2 antibody, hN2 antibody, NOTCH2 antibody, neurogenic locus notch homolog protein 2 antibody, Notch homolog 2 antibody, notch 2 antibody
Molecular Weight 265 kDa
UniProt Q04721
Comment

Positive Controls: A431 , HeLa , HepG2

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Van de Craen, Vandenabeele, Declercq et al.: "Characterization of seven murine caspase family members." in: FEBS letters, Vol. 403, Issue 1, pp. 61-9, 1997 (PubMed).

Wolf, Green: "Suicidal tendencies: apoptotic cell death by caspase family proteinases." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20049-52, 1999 (PubMed).

Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

Yoneda, Imaizumi, Oono et al.: "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress." in: The Journal of biological chemistry, Vol. 276, Issue 17, pp. 13935-40, 2001 (PubMed).

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