OAZ1 antibody (Middle Region)

Catalog No. ABIN5515002

Product Details anti-OAZ1 Antibody

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Binding Specificity: Middle Region

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAZ1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of rat OAZ1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Alternative Name: OAZ1 (OAZ1 Products)

Synonyms: AZI antibody, OAZ antibody, AZ-1 antibody, AZ1 antibody, Antizyme antibody, ODC-Az antibody, Oaz antibody, ODCAC antibody, oaz antibody, AZS antibody, oaz1 antibody, ornithine decarboxylase antizyme 1 antibody, ornithine decarboxylase antizyme 1 S homeolog antibody, ornithine decarboxylase antizyme 1a antibody, OAZ1 antibody, Oaz1 antibody, oaz1.S antibody, oaz1a antibody

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme,

Protein Size: 227

Gene ID: 18245

NCBI Accession: NM_008753, NP_032779

UniProt: P54369