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CBX7 antibody (C-Term)
CBX7
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CBX7 Antibody
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Target
See all CBX7 Antibodies
CBX7
(Chromobox Homolog 7 (CBX7))
Binding Specificity
All epitopes for CBX7 antibodies
C-Term
Reactivity
All reactivities for CBX7 antibodies
Human
Host
All hosts for CBX7 antibodies
Rabbit
Clonality
All clonalities for CBX7 antibodies
Polyclonal
Conjugate
All conjugates for CBX7 antibodies
This CBX7 antibody is un-conjugated
Application
All applications for CBX7 antibodies
Western Blotting (WB)
Sequence
LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA
Characteristics
This is a rabbit polyclonal antibody against CBX7. It was validated on Western Blot.
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human CBX7
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for CBX7
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Target
CBX7
(Chromobox Homolog 7 (CBX7))
Alternative Name
CBX7 (CBX7 Products )
Synonyms
1600014J01Rik antibody, AI851678 antibody, D15Ertd417e antibody, zgc:110152 antibody, chromobox 7 antibody, chromobox homolog 7a antibody, CBX7 antibody, Cbx7 antibody, cbx7a antibody
Background
CBX7 is a component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. Protein Size: 251
Gene ID
23492
NCBI Accession
NP_783640
UniProt
O95931
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