GPR31 antibody (C-Term)

Catalog No. ABIN5516748

Product Details anti-GPR31 Antibody

Target: GPR31 (G Protein-Coupled Receptor 31 (GPR31))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR31 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QKRLREPEKQ PKLQRAQALV TLVVVLFALC FLPCFLARVL MHIFQNLGSC

Characteristics: This is a rabbit polyclonal antibody against GPR31. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GPR31

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GPR31

Target: GPR31 (G Protein-Coupled Receptor 31 (GPR31))

Alternative Name: GPR31 (GPR31 Products)

Synonyms: 12-HETER antibody, HETER antibody, HETER1 antibody, GPR31 antibody, GPR31c(t) antibody, Gpr31 antibody, Gpr31c antibody, G protein-coupled receptor 31 antibody, G protein-coupled receptor 31, D17Leh66b region antibody, GPR31 antibody, Gpr31 antibody, Gpr31b antibody

Background: GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Alias Symbols: GPR31,

Protein Size: 319

Gene ID: 2853

NCBI Accession: NP_005290

UniProt: O00270