PLOD2 antibody (C-Term)

Catalog No. ABIN5517437

Product Details anti-PLOD2 Antibody

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLOD2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PIFSEKACDE LVEEMEHYGK WSGGKHHDSR ISGGYENVPT DDIHMKQVDL

Characteristics: This is a rabbit polyclonal antibody against PLOD2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLOD2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLOD2

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Alternative Name: PLOD2 (PLOD2 Products)

Synonyms: D530025C14Rik antibody, LH2 antibody, Plod-2 antibody, TLH antibody, procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 antibody, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 antibody, Plod2 antibody, PLOD2 antibody

Background: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: PLOD2,

Protein Interaction Partner: ITGB1BP2, SUPT5H, CSDE1, SF1, UGP2, TPP2, VASN, RNF123, NUSAP1, SAMHD1, DNPEP, GANAB, SWAP70, XPO7, PACSIN2, FAF1, HSPH1, SEC23A, PRMT3, FARSB, USP15, RANBP3, SET, RPL24, PTPN12, NCL, NARS, JUP, GART, XRCC6, AP2B1, gag-pol, UBL4A, OS9, FBXO6, UBC, VHL, Fa

Protein Size: 737

Gene ID: 5352

UniProt: O00469

Pathways: SARS-CoV-2 Protein Interactome