SPATA18 antibody (Middle Region)

Catalog No. ABIN5517765

Product Details anti-SPATA18 Antibody

Target: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPATA18 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ELKSLQAQED ARHRNTDQRS SENRRSEPWS LEERKREQWN SLKQNADQQD

Predicted Reactivity: Cow: 77%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SPATA18. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SPATA18

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPATA18

Target: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Alternative Name: SPATA18 (SPATA18 Products)

Synonyms: Mieap antibody, SPETEX1 antibody, 1700067I02Rik antibody, MIEAP antibody, spetex-1 antibody, mieap antibody, spetex1 antibody, im:7140046 antibody, zgc:110352 antibody, spermatogenesis associated 18 antibody, spermatogenesis associated 18 L homeolog antibody, SPATA18 antibody, Spata18 antibody, spata18.L antibody, spata18 antibody

Background: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

Alias Symbols: Mieap, SPETEX1

Protein Interaction Partner: PAXIP1,

Protein Size: 506

Gene ID: 132671

NCBI Accession: NM_001297608, NP_001284537