SMG6 antibody (Middle Region)

Catalog No. ABIN5517840

Product Details anti-SMG6 Antibody

Target: SMG6 (Smg-6 Homolog, Nonsense Mediated mRNA Decay Factor (SMG6))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DEVSPTSWGD SRQAQASYYK FQNSDNPYYY PRTPGPASQY PYTGYNPLQY

Characteristics: This is a rabbit polyclonal antibody against EST1A. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human EST1A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMG6

Target: SMG6 (Smg-6 Homolog, Nonsense Mediated mRNA Decay Factor (SMG6))

Alternative Name: EST1A (SMG6 Products)

Synonyms: AI317223 antibody, AU041178 antibody, EST1A antibody, C17orf31 antibody, SMG-6 antibody, hSMG5/7a antibody, Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) antibody, SMG6, nonsense mediated mRNA decay factor antibody, Smg6 antibody, SMG6 antibody

Background: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.

Alias Symbols: SMG6, C17orf31, EST1A, KIAA0732,

Protein Interaction Partner: UBC, SOX2, PPP1CC, gag-pol, UPF1, HBB, HDAC8, TERT, SMG5,

Protein Size: 1419

Gene ID: 23293

UniProt: Q86US8