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GSAP antibody (N-Term)

PION Reactivity: Human, Rat, Horse, Rabbit, Cow, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5517988
  • Target See all GSAP (PION) Antibodies
    GSAP (PION) (Pigeon Homolog (PION))
    Binding Specificity
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Rat, Horse, Rabbit, Cow, Dog
    Host
    • 15
    • 2
    • 1
    Rabbit
    Clonality
    • 17
    • 1
    Polyclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    This GSAP antibody is un-conjugated
    Application
    • 18
    • 13
    • 10
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    QTRQNELLYT FEKDLQVFSC SVNSERTLLA ASLVQSTKEG KRNELQPGSK
    Predicted Reactivity
    Cow: 85%, Dog: 85%, Horse: 93%, Human: 100%, Rabbit: 93%, Rat: 86%
    Characteristics
    This is a rabbit polyclonal antibody against GSAP. It was validated on Western Blot.
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human GSAP
    Top Product
    Discover our top product PION Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GSAP (PION) (Pigeon Homolog (PION))
    Alternative Name
    GSAP (PION Products)
    Synonyms
    PION antibody, A530088I07Rik antibody, Pion antibody, gamma-secretase activating protein antibody, GSAP antibody, Gsap antibody
    Background
    Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease. Formation of amyloid-beta is catalyzed by gamma-secretase, a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein C-terminal fragment (APP-CTF).

    Alias Symbols: GSAP, PION,

    Protein Size: 854
    Gene ID
    54103
    NCBI Accession
    NP_059135
    UniProt
    A4D1B5
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