Mitochondrial Ribosomal Protein S12 (MRPS12) (AA 1-138) antibody

Details for Product No. ABIN551818
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Antigen
Synonyms CG7925, Dmel\\CG7925, EG:BACH59J11.1, MRP-S12, MRPS12, S12, Tko, l(1)3Ab, l(1)tko, mRpS12, mt-rps12, rps12, MGC64304, GB10531, MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12, AI327385, Rpms12
Epitope
AA 1-138
(14), (8), (2), (1), (1), (1), (1)
Reactivity
Human
(25), (12), (3), (1), (1)
Host
Rabbit
(25), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (20), (8), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551818
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 138 of S12mt
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Mitochondrion
Purification Purified by antigen-affinity chromatography..
Alternative Name MRPS12
Background Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein. [provided by RefSeq]
Synonyms: MPR-S12 antibody, MT-RPS12 antibody, RPMS12 antibody, RPS12 antibody, RPSM12 antibody, MRPS12 antibody, "28S ribosomal protein S12, mitochondrial antibody", MRP-S12 antibody, S12mt antibody, mitochondrial ribosomal protein S12 antibody
Molecular Weight 15 kDa
UniProt O15235
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Baldwin: "The NF-kappa B and I kappa B proteins: new discoveries and insights." in: Annual review of immunology, Vol. 14, Issue 8, pp. 649-83, 1996 (PubMed).

Verma, Stevenson: "IkappaB kinase: beginning, not the end." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 22, pp. 11758-60, 1997 (PubMed).

Jungnickel, Staratschek-Jox, Bräuninger et al.: "Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 395-402, 2000 (PubMed).

Karin, Ben-Neriah: "Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity." in: Annual review of immunology, Vol. 18, Issue 8, pp. 621-63, 2000 (PubMed).

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