Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2) (AA 1-118) antibody

Details for Product No. ABIN551819
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Antigen
Synonyms 0610040H15Rik, cb162, wu:fb47e08, ELOB, SIII
Epitope
AA 1-118
(12), (8), (7), (7), (7), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(49), (23), (17), (13), (12), (12), (1)
Host
Rabbit
(36), (17), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(46), (29), (10), (9), (7), (3), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN551819
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 118 of Elongin B
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name TCEB2
Background This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq]
Synonyms: ELOB antibody, SIII antibody, TCEB2 antibody, elongin-B antibody, RNA polymerase II transcription factor SIII p18 subunit antibody, RNA polymerase II transcription factor SIII subunit B antibody, transcription elongation factor B polypeptide 2 antibody, elongin 18 kDa subunit antibody, "elongin, 18-kD subunit antibody", SIII p18 antibody, "transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) antibody"
Molecular Weight 13 kDa
UniProt Q15370
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.23 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Baldwin: "The NF-kappa B and I kappa B proteins: new discoveries and insights." in: Annual review of immunology, Vol. 14, Issue 8, pp. 649-83, 1996 (PubMed).

Verma, Stevenson: "IkappaB kinase: beginning, not the end." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 22, pp. 11758-60, 1997 (PubMed).

Jungnickel, Staratschek-Jox, Bräuninger et al.: "Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 395-402, 2000 (PubMed).

Karin, Ben-Neriah: "Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity." in: Annual review of immunology, Vol. 18, Issue 8, pp. 621-63, 2000 (PubMed).

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