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Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2) (AA 1-118) antibody

Details for Product No. ABIN551819, Supplier: Login to see
Antigen
  • 0610040H15Rik
  • cb162
  • wu:fb47e08
  • ELOB
  • SIII
Epitope
AA 1-118
16
16
15
11
8
3
2
2
2
2
1
1
1
1
Reactivity
Human
58
26
10
2
1
1
Host
Rabbit
55
18
1
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
4
4
4
1
Application
Western Blotting (WB)
62
42
13
9
2
2
2
1
1
1
1
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 118 of Elongin B
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name TCEB2 (TCEB2 Antibody Abstract)
Background This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq]
Synonyms: ELOB antibody, SIII antibody, TCEB2 antibody, elongin-B antibody, RNA polymerase II transcription factor SIII p18 subunit antibody, RNA polymerase II transcription factor SIII subunit B antibody, transcription elongation factor B polypeptide 2 antibody, elongin 18 kDa subunit antibody, "elongin, 18-kD subunit antibody", SIII p18 antibody, "transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) antibody"
Molecular Weight 13 kDa
UniProt Q15370
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.23 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Karin, Ben-Neriah: "Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity." in: Annual review of immunology, Vol. 18, Issue 8, pp. 621-63, 2000 (PubMed).

Jungnickel, Staratschek-Jox, Bräuninger et al.: "Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 395-402, 2000 (PubMed).

Background publications Verma, Stevenson: "IkappaB kinase: beginning, not the end." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 22, pp. 11758-60, 1997 (PubMed).

Baldwin: "The NF-kappa B and I kappa B proteins: new discoveries and insights." in: Annual review of immunology, Vol. 14, Issue 8, pp. 649-83, 1996 (PubMed).