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COL2A1 antibody (C-Term)

COL2A1 Reactivity: Mouse, Rat WB, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5518709
  • Target See all COL2A1 Antibodies
    COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
    Binding Specificity
    • 15
    • 14
    • 9
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1222-1241, C-Term
    Reactivity
    • 66
    • 31
    • 29
    • 19
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 69
    • 10
    • 2
    • 1
    Rabbit
    Clonality
    • 73
    • 9
    Polyclonal
    Conjugate
    • 49
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This COL2A1 antibody is un-conjugated
    Application
    • 63
    • 37
    • 22
    • 18
    • 17
    • 13
    • 13
    • 13
    • 9
    • 9
    • 8
    • 7
    • 3
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Purpose
    Rabbit IgG polyclonal antibody for Collagen alpha-1(II) chain(COL2A1) detection. Tested with WB, IHC-F in Mouse,Rat.
    Sequence
    AFAGLGQREK GPDPMQYMRA
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Collagen alpha-1(II) chain(COL2A1) detection. Tested with WB, IHC-F in Mouse,Rat.
    Gene Name: collagen, type II, alpha 1
    Protein Name: Collagen alpha-1(II) chain
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of mouse Collagen II1222-1241aa AFAGLGQREKGPDPMQYMRA), different from the related rat sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product COL2A1 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Mouse, The detection limit for COL2A1 is approximately 1 ng/lane under reducing conditions.
    IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(F).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Sodium azide, Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Jia, Ma, Lv, Ma, Xu, Yang, Tian, Wang, Sun, Xu, Fu, Zhao: "Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity." in: Scientific reports, Vol. 6, pp. 27521, (2018) (PubMed).

    Li, Zou, Wang, Wang, Li, Chen, Sun, Sun: "TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes." in: Toxins, Vol. 9, Issue 11, (2018) (PubMed).

    Liang, Sun, Wei, Zhang, Li, Xu, Shang, Deng, Zhao, Wei: "Establishment of rat ankle post-traumatic osteoarthritis model induced by malleolus fracture." in: BMC musculoskeletal disorders, Vol. 18, Issue 1, pp. 464, (2018) (PubMed).

    Qin, Jin, Jiang, Li, Tan, Wu, Zheng, Zhao: "A Human Chondrocyte-Derived In Vitro Model of Alcohol-Induced and Steroid-Induced Femoral Head Necrosis." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 539-547, (2018) (PubMed).

    Jiang, Zhong, Zheng, Zhao: "Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 2150-2158, (2018) (PubMed).

    Zeng, Xiao, Deng, Li: "Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 8985623, (2017) (PubMed).

    Huang, Wu, Wang, Zheng, Zhao: "Protective effects of baicalin on rabbit articular chondrocytes in vitro." in: Experimental and therapeutic medicine, Vol. 13, Issue 4, pp. 1267-1274, (2017) (PubMed).

    Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." in: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).

    Tian, Zhong, Zheng, Zhang, Liu, Zhang, Liu: "Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3." in: Scientific reports, Vol. 5, pp. 15101, (2016) (PubMed).

    Liu, Tian, Zhou, Wang, Gou, Zhang, Wang, Shen, Zhang, Zhang: "Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat." in: BMC musculoskeletal disorders, Vol. 16, pp. 342, (2016) (PubMed).

    Tian, Zhong, Zhang, Yin, Zhang, Liu: "Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation." in: Molecular medicine reports, Vol. 13, Issue 1, pp. 67-74, (2016) (PubMed).

    Gu, Li, Li, Yu, Wang, Ding, Liu: "Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet." in: Nutrients, Vol. 8, Issue 4, pp. 233, (2016) (PubMed).

    Li, Sun, Liu, Chen, Rong, Lou, Yang, Yang, Liu: "Use of a biological reactor and platelet-rich plasma for the construction of tissue-engineered bone to repair articular cartilage defects." in: Experimental and therapeutic medicine, Vol. 12, Issue 2, pp. 711-719, (2016) (PubMed).

    Liu, Lu, Wu, Zheng: "Chondroprotective effects of taurine in primary cultures of human articular chondrocytes." in: The Tohoku journal of experimental medicine, Vol. 235, Issue 3, pp. 201-13, (2015) (PubMed).

    Ye, Wu, Li, Li, Zheng, Liu, Ye: "Millimeter Wave Treatment Inhibits Apoptosis of Chondrocytes via Regulation Dynamic Equilibrium of Intracellular Free Ca (2+)." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 464161, (2015) (PubMed).

    Cai, Zhang, Zhang, Ge, Dai, Tan, Roodrajeetsing, Cai: "Promoting Effects on Proliferation and Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Four "Kidney-Tonifying" Traditional Chinese Herbs." in: BioMed research international, Vol. 2015, pp. 792161, (2015) (PubMed).

    Sun, Meng, Li, Liu, Chen: "Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold." in: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1482-1488, (2015) (PubMed).

    Wang, Yao, Huang, Li, Xu: "Effects of TGF-β1 and alginate on the differentiation of rabbit bone marrow-derived mesenchymal stem cells into a chondrocyte cell lineage." in: Experimental and therapeutic medicine, Vol. 10, Issue 3, pp. 995-1002, (2015) (PubMed).

    Ouyang, Wang, Hong, Xin, Wang, Yang, Wang, Wang, Wei, Wang, Cui: "Establishment of a rat model for osteoarthritis resulting from anterior cruciate ligament rupture and its significance." in: Experimental and therapeutic medicine, Vol. 10, Issue 6, pp. 2035-2038, (2015) (PubMed).

    Liu, Liu, Lin, Wei, Zheng: "Effect of JEZTC, a synthetic compound, on proliferation and phenotype maintenance of rabbit articular chondrocytes in vitro." in: In vitro cellular & developmental biology. Animal, Vol. 50, Issue 10, pp. 982-91, (2014) (PubMed).

  • Target
    COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
    Alternative Name
    COL2A1 (COL2A1 Products)
    Synonyms
    ANFH antibody, AOM antibody, COL11A3 antibody, SEDC antibody, Col2 antibody, Col2a antibody, Col2a-1 antibody, Del1 antibody, Dmm antibody, Lpk antibody, M100856 antibody, Rgsc856 antibody, CG2A1A antibody, COLLII antibody, col2a1a antibody, CB11 antibody, col2a1 antibody, coll2a1 antibody, fb38c06 antibody, fc10c01 antibody, wu:fb38c06 antibody, wu:fc10c01 antibody, collagen type II alpha 1 chain antibody, collagen, type II, alpha 1 antibody, collagen, type II, alpha 1 L homeolog antibody, collagen, type II, alpha 1 S homeolog antibody, collagen, type II, alpha 1a antibody, COL2A1 antibody, Col2a1 antibody, col2a1 antibody, col2a1.L antibody, col2a1.S antibody, col2a1a antibody
    Background
    Collagen, type II, alpha 1, also known as COL2A1, is a human gene which is the major collagen synthesized by chondrocvtes. COL2A1 is mapped to 12q13.11. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

    Synonyms: Alpha 1 type II collagen antibody|Alpha-1 type II collagen antibody|AOM antibody|Cartilage collagen antibody|Chondrocalcin antibody|CO2A1_HUMAN antibody|COL11A3 antibody|COL2A1 antibody|COL2A1 protein antibody|Collagen alpha 1(II) chain precursor antibody|Collagen II alpha 1 polypeptide antibody|Collagen type II alpha 1(primary osteoarthritis spondyloepiphyseal dysplasia congenital) antibody|MGC131516 antibody|SEDC antibody
    UniProt
    P28481
    Pathways
    Sensory Perception of Sound, Growth Factor Binding
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