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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 455-518) antibody

Details for Product No. ABIN552783, Supplier: Login to see
Antigen
  • RIPK3
  • RIP3
  • 2610528K09Rik
  • AW107945
  • Rip3
  • Hcyp2
Epitope
AA 455-518
32
20
16
15
10
7
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Human
117
40
16
7
6
4
2
1
Host
Rabbit
123
24
Clonality
Polyclonal
Conjugate
Un-conjugated
9
7
5
5
5
5
1
Application
ELISA
131
61
60
24
7
4
3
3
2
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to a region within amino acids 455 and 518 of RIP3
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Cytoplasm
Purification Purified by antigen-affinity chromatography..
Alternative Name RIPK3 / RIP3 (RIPK3 Antibody Abstract)
Background The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq]
Synonyms: RIP3 antibody, RIPK3 antibody, receptor interacting protein 3 antibody, receptor-interacting serine/threonine-protein kinase 3 antibody, RIP-like protein kinase 3 antibody, receptor-interacting protein 3 antibody, RIP-3 antibody, receptor-interacting serine-threonine kinase 3 antibody
Molecular Weight 57 kDa
UniProt Q9Y572
Pathways
Comment

Positive Controls: Synthetic peptide: 1:8,000

Restrictions For Research Use only
Format Liquid
Concentration 0.68 mg/mL
Buffer 1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Salvesen, Duckett: "IAP proteins: blocking the road to death's door." in: Nature reviews. Molecular cell biology, Vol. 3, Issue 6, pp. 401-10, 2002 (PubMed).

Goyal: "Cell death inhibition: keeping caspases in check." in: Cell, Vol. 104, Issue 6, pp. 805-8, 2001 (PubMed).

Roy, Mahadevan, McLean et al.: "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy." in: Cell, Vol. 80, Issue 1, pp. 167-78, 1995 (PubMed).

Background publications Deveraux, Reed: "IAP family proteins--suppressors of apoptosis." in: Genes & development, Vol. 13, Issue 3, pp. 239-52, 1999 (PubMed).

Roy, Deveraux, Takahashi et al.: "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases." in: The EMBO journal, Vol. 16, Issue 23, pp. 6914-25, 1998 (PubMed).

Rothe, Pan, Henzel et al.: "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins." in: Cell, Vol. 83, Issue 7, pp. 1243-52, 1996 (PubMed).