PDZD3 antibody (AA 258-285)

Catalog No. ABIN5537302

Product Details anti-PDZD3 Antibody

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Binding Specificity: AA 258-285

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDZD3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PDZD3

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Alternative Name: PDZD3 (PDZD3 Products)

Synonyms: RGD1559807 antibody, zgc:194812 antibody, IKEPP antibody, NHERF4 antibody, PDZK2 antibody, NaPi-Cap2 antibody, Pdzk2 antibody, PDZ domain containing 3 antibody, PDZ domain containing 3b antibody, Pdzd3 antibody, pdzd3b antibody, PDZD3 antibody

Background: Guanylyl cyclase C (GCC, or GUCY2C, MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR, MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).

Molecular Weight: 61 kDa

Gene ID: 79849

UniProt: Q86UT5