anti-PIK3R5 antibody (Phosphoinositide-3-Kinase, Regulatory Subunit 5) (Regulatory Subunit 5)

Details for Product anti-PIK3R5 Antibody No. ABIN554069
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Synonyms F730038I15Rik, FOAP-2, P101-PI3K, p101, P101, RGD1563261, AV230647
Regulatory Subunit 5, AA 603-880
(16), (16), (8), (7), (3), (3), (2), (1), (1), (1), (1)
(78), (20), (13), (9), (8), (1), (1), (1), (1)
(50), (28)
This PIK3R5 antibody is un-conjugated
(3), (3), (3), (3), (3), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(67), (30), (29), (28), (16), (16), (9), (3), (2), (1)
Pubmed 6 references available
Quantity 0.1 mL
Shipping to United States ( )
Immunogen Recombinant fragment corresponding to a region within amino acids 603 and 880 of PI3 kinase p101
Isotype IgG
Cross-Reactivity Pig (Porcine)
Predicted Reactivity Mouse (88%), Pig (92%), Rat (88%)
Characteristics Cellular Localization: Nucleus (By similarity) , Cytoplasm (By similarity) , Membrane, Peripheral membrane protein
Purification Purified by antigen-affinity chromatography..
Alternative Name PIK3R5 (PIK3R5 Antibody Abstract)
Background Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).[supplied by OMIM]
Synonyms: F730038I15Rik antibody, FOAP-2 antibody, P101-PI3K antibody, p101 antibody, PIK3R5 antibody, phosphoinositide 3-kinase regulatory subunit 5 antibody, "phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit antibody", protein FOAP-2 antibody, ptdIns-3-kinase p101 antibody, PI3-kinase p101 subunit antibody, "phosphoinositide-3-kinase, regulatory subunit 5 antibody"
Molecular Weight 97 kDa
UniProt Q8WYR1
Pathways PI3K-Akt Signaling

Positive Controls: FFPE normal human esophagus

Restrictions For Research Use only
Format Liquid
Concentration 0.99 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Gorospe, Liu, Xu et al.: "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 762-70, 1996 (PubMed).

Polyak, Kato, Solomon et al.: "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest." in: Genes & development, Vol. 8, Issue 1, pp. 9-22, 1994 (PubMed).

Nourse, Firpo, Flanagan et al.: "Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin." in: Nature, Vol. 372, Issue 6506, pp. 570-3, 1995 (PubMed).

Background publications Sherr: "Mammalian G1 cyclins." in: Cell, Vol. 73, Issue 6, pp. 1059-65, 1993 (PubMed).

Toyoshima, Hunter: "p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21." in: Cell, Vol. 78, Issue 1, pp. 67-74, 1994 (PubMed).

Polyak, Lee, Erdjument-Bromage et al.: "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals." in: Cell, Vol. 78, Issue 1, pp. 59-66, 1994 (PubMed).

Catalog No. ABIN554069
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