Phosphoinositide-3-Kinase, Regulatory Subunit 5 (PIK3R5) (AA 603-880), (Regulatory Subunit 5) antibody

Details for Product No. ABIN554069
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Synonyms F730038I15Rik, FOAP-2, P101-PI3K, p101, P101, RGD1563261, AV230647
Regulatory Subunit 5, AA 603-880
(17), (16), (8), (7), (3), (3), (1), (1), (1), (1), (1)
(71), (17), (9), (5), (4), (1), (1), (1), (1)
(52), (19)
(3), (3), (3), (3), (3), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(59), (30), (29), (21), (16), (9), (3), (2), (1), (1)
Pubmed 6 references available
Quantity 0.1 mL
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Immunogen Recombinant fragment corresponding to a region within amino acids 603 and 880 of PI3 kinase p101
Isotype IgG
Cross-Reactivity Pig (Porcine)
Predicted Reactivity Mouse (88%), Pig (92%), Rat (88%)
Characteristics Cellular Localization: Nucleus (By similarity) , Cytoplasm (By similarity) , Membrane, Peripheral membrane protein
Purification Purified by antigen-affinity chromatography..
Alternative Name PIK3R5 (PIK3R5 Antibody Abstract)
Background Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).[supplied by OMIM]
Synonyms: F730038I15Rik antibody, FOAP-2 antibody, P101-PI3K antibody, p101 antibody, PIK3R5 antibody, phosphoinositide 3-kinase regulatory subunit 5 antibody, "phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit antibody", protein FOAP-2 antibody, ptdIns-3-kinase p101 antibody, PI3-kinase p101 subunit antibody, "phosphoinositide-3-kinase, regulatory subunit 5 antibody"
Molecular Weight 97 kDa
UniProt Q8WYR1
Pathways PI3K-Akt Signaling Pathway

Positive Controls: FFPE normal human esophagus

Restrictions For Research Use only
Format Liquid
Concentration 0.99 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Gorospe, Liu, Xu et al.: "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 762-70, 1996 (PubMed).

Polyak, Kato, Solomon et al.: "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest." in: Genes & development, Vol. 8, Issue 1, pp. 9-22, 1994 (PubMed).

Nourse, Firpo, Flanagan et al.: "Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin." in: Nature, Vol. 372, Issue 6506, pp. 570-3, 1995 (PubMed).

Background publications Sherr: "Mammalian G1 cyclins." in: Cell, Vol. 73, Issue 6, pp. 1059-65, 1993 (PubMed).

Toyoshima, Hunter: "p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21." in: Cell, Vol. 78, Issue 1, pp. 67-74, 1994 (PubMed).

Polyak, Lee, Erdjument-Bromage et al.: "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals." in: Cell, Vol. 78, Issue 1, pp. 59-66, 1994 (PubMed).

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Catalog No. ABIN554069
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