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Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody

Details for Product No. ABIN554103, Supplier: Login to see
Antigen
  • wu:fd15e01
  • wu:fi37e08
  • PKLR
  • cthbp
  • oip3
  • pk3
  • pklr
  • pkm2
  • tcb
  • thbp1
  • pk1
  • Pk-1
  • Pk1
  • R-PK
  • PK1
  • PKL
  • PKR
  • PKRL
  • RPK
  • Pklg
Epitope
AA 254-574
27
21
8
8
5
5
5
3
2
2
2
1
1
1
1
Reactivity
Human
113
22
12
5
3
1
1
Host
Rabbit
79
40
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
4
4
4
4
Application
Western Blotting (WB)
95
56
38
18
18
12
8
3
2
1
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 254 and 574 of
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified by antigen-affinity chromatography..
Alternative Name PKLR (PKLR Antibody Abstract)
Background The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: PK1 antibody, PKL antibody, PKR antibody, PKRL antibody, RPK antibody, PKLR antibody, R-type/L-type pyruvate kinase antibody, pyruvate kinase type L antibody, red cell/liver pyruvate kinase antibody, pyruvate kinase 1 antibody, pyruvate kinase isozyme R/L antibody, pyruvate kinase, liver and blood cell antibody, pyruvate kinase isozymes R/L antibody, pyruvate kinase, liver and RBC antibody
Molecular Weight 62 kDa
UniProt P30613
Research Area Cancer, Metabolism
Pathways
Comment

Positive Controls: Jurkat , Raji , K562 , THP-1 , NCI-H929 , mouse liver , rat liver

Restrictions For Research Use only
Format Liquid
Concentration 0.15 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Western Blotting (WB) image for anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody (ABIN554103) anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody
Western Blotting (WB) image for anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody (ABIN554103) anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody (Image 2)
Western Blotting (WB) image for anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody (ABIN554103) anti-Pyruvate Kinase, Liver and RBC (PKLR) (AA 254-574) antibody (Image 3)
Background publications Krajewski, Bodrug, Krajewska et al.: "Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo." in: The American journal of pathology, Vol. 146, Issue 6, pp. 1309-19, 1995 (PubMed).

Kozopas, Yang, Buchan et al.: "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3516-20, 1993 (PubMed).