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Tyrosine-Protein Kinase JAK3 (JAK3) (AA 287-569) antibody

Details for Product No. ABIN554105
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Antigen
Synonyms JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, fae, wil, RATJAK3, JAK
Epitope
AA 287-569
(17), (12), (12), (6), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(74), (60), (48), (37), (37), (25), (1)
Host
Rabbit
(59), (18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(41), (30), (27), (13), (11), (10), (7), (5), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN554105
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Immunogen Recombinant fragment contain a sequence corresponding to a region within amino acids 287 and 569 of JAK3
Isotype IgG
Characteristics Cellular Localization: Endomembrane system, Peripheral membrane protein (By similarity)
Purification Purified by antigen-affinity chromatography..
Alternative Name Tyrosine-protein kinase JAK3
Background The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq]
Synonyms: JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, JAK3 antibody, tyrosine-protein kinase JAK3 antibody, leukocyte Janus kinase antibody, "Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody", Janus kinase 3 antibody
Molecular Weight 125 kDa
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Davis: "MAPKs: new JNK expands the group." in: Trends in biochemical sciences, Vol. 19, Issue 11, pp. 470-3, 1995 (PubMed).

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