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JAK3 antibody (Tyrosine-Protein Kinase JAK3) (AA 287-569)

Details for Product anti-JAK3 Antibody No. ABIN554105, Supplier: Login to see
Antigen
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • fae
  • wil
  • RATJAK3
  • JAK
Alternatives
anti-Human JAK3 antibody for Immunohistochemistry
Epitope
AA 287-569
15
15
13
13
12
8
7
7
6
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
85
57
41
2
2
2
2
1
1
1
Host
Rabbit
66
23
Clonality
Polyclonal
Conjugate
This JAK3 antibody is un-conjugated
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Application
Western Blotting (WB)
52
37
24
15
10
10
9
7
2
2
1
1
1
Supplier
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Immunogen Recombinant fragment contain a sequence corresponding to a region within amino acids 287 and 569 of JAK3
Isotype IgG
Characteristics Cellular Localization: Endomembrane system, Peripheral membrane protein (By similarity)
Purification Purified by antigen-affinity chromatography..
Alternative Name Tyrosine-protein kinase JAK3 (JAK3 Antibody Abstract)
Background The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq]
Synonyms: JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, JAK3 antibody, tyrosine-protein kinase JAK3 antibody, leukocyte Janus kinase antibody, "Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody", Janus kinase 3 antibody
Molecular Weight 125 kDa
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Davis: "MAPKs: new JNK expands the group." in: Trends in biochemical sciences, Vol. 19, Issue 11, pp. 470-3, 1995 (PubMed).