Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody

Details for Product No. ABIN554130
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Antigen
Synonyms Adrbk-1, Bark-1, GRK2, betaARK1, BARK1, BETA-ARK1, GRK-2, Grk2
Epitope
AA 322-689
(12), (9), (5), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(96), (58), (57), (15), (15), (13), (12), (12), (7), (1)
Host
Rabbit
(77), (16), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(84), (56), (40), (13), (11), (10), (9), (3), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN554130
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Immunogen Recombinant fragment corresponding to a region within amino acids 322 and 689 of GRK2
Isotype IgG
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Chicken (90%), Rat (98%), Bovine (99%)
Purification Purified by antigen-affinity chromatography..
Alternative Name Beta-ARK-1 / ADRBK1
Background The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]
Synonyms: BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody, ADRBK1 antibody, G-protein coupled receptor kinase 2 antibody, beta-ARK-1 antibody, beta-adrenergic receptor kinase 1 antibody, "adrenergic, beta, receptor kinase 1 antibody"
Molecular Weight 80 kDa
UniProt P25098
Comment

Positive Controls: H1299 , Molt-4 , Raji

Restrictions For Research Use only
Format Liquid
Concentration 0.8 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Dias, Parham, Shapiro et al.: "Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope mapping and diagnostic utility." in: Cancer research, Vol. 52, Issue 23, pp. 6431-9, 1992 (PubMed).

Davis, Weintraub, Lassar: "Expression of a single transfected cDNA converts fibroblasts to myoblasts." in: Cell, Vol. 51, Issue 6, pp. 987-1000, 1988 (PubMed).

Dias, Dilling, Houghton: "The molecular basis of skeletal muscle differentiation." in: Seminars in diagnostic pathology, Vol. 11, Issue 1, pp. 3-14, 1994 (PubMed).

Rawls, Valdez, Zhang et al.: "Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice." in: Development (Cambridge, England), Vol. 125, Issue 13, pp. 2349-58, 1998 (PubMed).

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