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Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody

Details for Product No. ABIN554130, Supplier: Login to see
Antigen
  • Adrbk-1
  • Bark-1
  • GRK2
  • betaARK1
  • BARK1
  • BETA-ARK1
  • GRK-2
  • Grk2
Alternatives
anti-Human Adrenergic, Beta, Receptor Kinase 1 antibody for Western Blotting
Epitope
AA 322-689
14
13
7
6
5
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
102
44
42
6
6
5
5
1
1
Host
Rabbit
71
17
16
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
95
64
37
11
11
8
4
2
1
1
1
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 322 and 689 of GRK2
Isotype IgG
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Chicken (90%), Rat (98%), Bovine (99%)
Purification Purified by antigen-affinity chromatography..
Alternative Name beta-ARK-1 / ADRBK1 (ADRBK1 Antibody Abstract)
Background The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]
Synonyms: BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody, ADRBK1 antibody, G-protein coupled receptor kinase 2 antibody, beta-ARK-1 antibody, beta-adrenergic receptor kinase 1 antibody, "adrenergic, beta, receptor kinase 1 antibody"
Molecular Weight 80 kDa
UniProt P25098
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Comment

Positive Controls: H1299 , Molt-4 , Raji

Restrictions For Research Use only
Format Liquid
Concentration 0.8 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody (ABIN554130) anti-Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody
Western Blotting (WB) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody (ABIN554130) anti-Adrenergic, Beta, Receptor Kinase 1 (ADRB1) (AA 322-689) antibody (Image 2)
Product cited in: Rawls, Valdez, Zhang et al.: "Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice." in: Development (Cambridge, England), Vol. 125, Issue 13, pp. 2349-58, 1998 (PubMed).

Davis, Weintraub, Lassar: "Expression of a single transfected cDNA converts fibroblasts to myoblasts." in: Cell, Vol. 51, Issue 6, pp. 987-1000, 1988 (PubMed).

Background publications Dias, Dilling, Houghton: "The molecular basis of skeletal muscle differentiation." in: Seminars in diagnostic pathology, Vol. 11, Issue 1, pp. 3-14, 1994 (PubMed).

Dias, Parham, Shapiro et al.: "Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope mapping and diagnostic utility." in: Cancer research, Vol. 52, Issue 23, pp. 6431-9, 1992 (PubMed).