Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 232-529) antibody

Details for Product No. ABIN554164
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Antigen
Synonyms p55-Fgr, SRC2, c-fgr, c-src2, p55c-fgr, p58-Fgr, p58c-fgr
Epitope
AA 232-529
(10), (6), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(85), (35), (25), (13), (12), (12)
Host
Rabbit
(59), (21), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(78), (42), (19), (19), (10), (6), (4), (4), (2)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN554164
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Immunogen Recombinant fragment corresponding to a region within amino acids 232 and 529 of FGR
Isotype IgG
Predicted Reactivity Human (100%)
Purification Purified by antigen-affinity chromatography..
Alternative Name FGR / SRC2
Background This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Synonyms: FLJ43153 antibody, MGC75096 antibody, SRC2 antibody, c-fgr antibody, c-src2 antibody, p55-Fgr antibody, p55c-fgr antibody, p58c-fgr antibody, FGR antibody, c-src-2 proto-oncogene antibody, tyrosine-protein kinase Fgr antibody, proto-oncogene c-Fgr antibody, proto-oncogene tyrosine-protein kinase FGR antibody, c-fgr protooncogene antibody, p55-c-fgr protein antibody, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody
Molecular Weight 59 kDa
UniProt P09769
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Livingston: "Functional analysis of the retinoblastoma gene product and of RB-SV40 T antigen complexes." in: Cancer surveys, Vol. 12, Issue 6, pp. 153-60, 1992 (PubMed).

Dunaief, Strober, Guha et al.: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, 1994 (PubMed).

Cordon-Cardo, Richon: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, 1994 (PubMed).

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