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Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 232-529) antibody

Details for Product No. ABIN554164, Supplier: Login to see
Antigen
  • p55-Fgr
  • SRC2
  • c-fgr
  • c-src2
  • p55c-fgr
  • p58-Fgr
  • p58c-fgr
Epitope
AA 232-529
20
19
7
6
6
4
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
112
46
24
3
1
1
Host
Rabbit
76
29
21
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
113
64
34
21
11
9
4
3
2
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 232 and 529 of FGR
Isotype IgG
Predicted Reactivity Human (100%)
Purification Purified by antigen-affinity chromatography..
Alternative Name FGR / SRC2 (FGR Antibody Abstract)
Background This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Synonyms: FLJ43153 antibody, MGC75096 antibody, SRC2 antibody, c-fgr antibody, c-src2 antibody, p55-Fgr antibody, p55c-fgr antibody, p58c-fgr antibody, FGR antibody, c-src-2 proto-oncogene antibody, tyrosine-protein kinase Fgr antibody, proto-oncogene c-Fgr antibody, proto-oncogene tyrosine-protein kinase FGR antibody, c-fgr protooncogene antibody, p55-c-fgr protein antibody, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody
Molecular Weight 59 kDa
UniProt P09769
Pathways
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Cordon-Cardo, Richon: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, 1994 (PubMed).

Dunaief, Strober, Guha et al.: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, 1994 (PubMed).

Livingston: "Functional analysis of the retinoblastoma gene product and of RB-SV40 T antigen complexes." in: Cancer surveys, Vol. 12, Issue 6, pp. 153-60, 1992 (PubMed).