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IL3RA antibody

IL3RA Reactivity: Human WB, FACS, IP, IHC (fro) Host: Mouse Monoclonal 6H6 unconjugated
Catalog No. ABIN5541978
  • Target See all IL3RA Antibodies
    IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
    Reactivity
    • 81
    • 26
    • 3
    Human
    Host
    • 48
    • 36
    • 3
    • 1
    Mouse
    Clonality
    • 45
    • 42
    • 1
    Monoclonal
    Conjugate
    • 45
    • 8
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL3RA antibody is un-conjugated
    Application
    • 60
    • 50
    • 19
    • 15
    • 13
    • 13
    • 10
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody recognizes CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
    Purification
    Affinity Chromatography on Protein A
    Immunogen
    IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
    Clone
    6H6
    Isotype
    IgG1
    Top Product
    Discover our top product IL3RA Primary Antibody
  • Application Notes
    Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on Frozen Sections.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    95 % pure by SDS-PAGE) Purified
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Martín-Gayo, Sierra-Filardi, Corbí, Toribio: "Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development." in: Blood, Vol. 115, Issue 26, pp. 5366-75, (2010) (PubMed).

    Nazareth, Broderick, Simpson-Abelson, Kelleher, Yokota, Bankert: "Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 9, pp. 5552-62, (2007) (PubMed).

    Mayr, Bund, Schlee, Moosmann, Kofler, Hallek, Wendtner: "Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes." in: Blood, Vol. 105, Issue 4, pp. 1566-73, (2005) (PubMed).

    Herling, Teitell, Shen, Medeiros, Jones: "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin." in: Blood, Vol. 101, Issue 12, pp. 5007-9, (2003) (PubMed).

  • Target
    IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
    Alternative Name
    cd123,il3ra (IL3RA Products)
    Synonyms
    CD123 antibody, IL3R antibody, IL3RAY antibody, IL3RX antibody, IL3RY antibody, hIL-3Ra antibody, CDw123 antibody, SUT-1 antibody, Cyrl antibody, interleukin 3 receptor subunit alpha antibody, interleukin 3 receptor, alpha chain antibody, IL3RA antibody, Il3ra antibody
    Background
    CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
    UniProt
    P26951
    Pathways
    JAK-STAT Signaling
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