Oxysterol Binding Protein 2 (OSBP2) (AA 854-916) antibody

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Antigen
Synonyms ORP-4, ORP4, OSBPL1, OSBPL4, 1700095P05Rik, C630001G20Rik, Gm244, RGD1309479
Epitope
AA 854-916
(12), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(34), (16), (16), (3), (3), (3), (1), (1)
Host
Rabbit
(19), (15), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(15), (11), (11), (5)
Pubmed 3 references available
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Quantity 0.1 mL
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Immunogen Synthetic peptide corresponding to a region within amino acids 854 and 916 of OSBP2
Isotype IgG
Predicted Reactivity Human (100%), Mouse (92%), Rat (92%), Bovine (92%)
Characteristics Cellular Localization: Membrane, Peripheral membrane protein
Purification Purified by antigen-affinity chromatography..
Alternative Name OSBP2 (OSBP2 Antibody Abstract)
Background Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq]
Synonyms: ORP-4 antibody, ORP4 antibody, OSBPL1 antibody, OSBPL4 antibody, OSBP2 antibody, OSBP-related protein 4 antibody, oxysterol-binding protein-related protein 4 antibody, oxysterol binding protein-like 1 antibody, oxysterol binding protein-related protein 4 antibody, oxysterol-binding protein 2 antibody, oxysterol binding protein 2 antibody
Molecular Weight 101 kDa
UniProt Q969R2
Research Area Signaling, Metabolism
Comment

Positive Controls: Synthetic peptide: 1:8,000

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Dyson, Dembski, Fattaey et al.: "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1." in: Journal of virology, Vol. 67, Issue 12, pp. 7641-7, 1993 (PubMed).

Saito, Helin, Valentine et al.: "Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line." in: Genomics, Vol. 25, Issue 1, pp. 130-8, 1995 (PubMed).

Nevins: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, 1992 (PubMed).

Catalog No. ABIN554213
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