CSF2RA antibody

Catalog No. ABIN5542180

Product Details anti-CSF2RA Antibody

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSF2RA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody recognizes Human CD116, the GM-CSF receptor alpha subunit (approx. 80 kDa) expressed e.g. by neutrophils, eosinophils, monocytes and macrophages.

Purification: Affinity Chromatography on Protein A

Immunogen: CD116-transfected COS cells

Clone: 4H1

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on Frozen Sections.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 95 % by SDS-PAGE) Purified

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

References for anti-CSF2RA antibody (ABIN5542180)

Kim, Kim, Bae, Ma, Kim: "Decreased Renal Expression of H(+)-ATPase and Pendrin in a Patient with Distal Renal Tubular Acidosis Associated with Sjögren's Syndrome." in: Internal medicine (Tokyo, Japan), Vol. 54, Issue 22, pp. 2899-904, (2016) (PubMed).

Ungar, Anafy, Yanai, Ron, Yavzori, Picard, Fudim, Loebstein, Kopylov, Chowers, Dotan, Eliakim, Ben-Horin: "Significance of low level infliximab in the absence of anti-infliximab antibodies." in: World journal of gastroenterology, Vol. 21, Issue 6, pp. 1907-14, (2015) (PubMed).

Lee, Lee, Lee, Kang, Park, Kim, Park, Yoon, Ha, Park, Lee, Cheon, Park: "Identification of a subnuclear body involved in sequence-specific cytokine RNA processing." in: Nature communications, Vol. 6, pp. 5791, (2015) (PubMed).

Schwarzmaier, Foell, Weinhage, Varga, Däbritz: "Peripheral monocyte functions and activation in patients with quiescent Crohn's disease." in: PLoS ONE, Vol. 8, Issue 4, pp. e62761, (2013) (PubMed).

Koba, Haruta, Matsunaga, Matsumura, Haga, Sasaki, Ikeda, Takamatsu, Nishimura, Senju: "Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-? against peritoneally disseminated cancer in xenograft models." in: PLoS ONE, Vol. 8, Issue 6, pp. e67567, (2013) (PubMed).

Krämer, Kess, Kremmer, Schulte-Hostede: "Multi-parameter determination of TNF?, PCT and CRP for point-of-care testing." in: The Analyst, Vol. 136, Issue 4, pp. 692-5, (2011) (PubMed).

Huntington, Legrand, Alves, Jaron, Weijer, Plet, Corcuff, Mortier, Jacques, Spits, Di Santo: "IL-15 trans-presentation promotes human NK cell development and differentiation in vivo." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 25-34, (2009) (PubMed).

Ohyama, Kato-Kogoe, Kuhara, Nishimura, Nakasho, Yamanegi, Yamada, Hata, Yamane, Terada: "The involvement of IL-23 and the Th17 pathway in periodontitis." in: Journal of dental research, Vol. 88, Issue 7, pp. 633-8, (2009) (PubMed).

Meyer, Hartmann, Krause, Blankenstein, Mueller-Chorus, Oster, Miethe, Keusgen: "CRP determination based on a novel magnetic biosensor." in: Biosensors & bioelectronics, Vol. 22, Issue 6, pp. 973-9, (2007) (PubMed).

Pankiv, Clausen, Lamark, Brech, Bruun, Outzen, Øvervatn, Bjørkøy, Johansen: "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy." in: The Journal of biological chemistry, Vol. 282, Issue 33, pp. 24131-45, (2007) (PubMed).

Target Details for CSF2RA

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Alternative Name: cd116,csf2ra (CSF2RA Products)

Synonyms: CD116 antibody, CDw116 antibody, CSF2R antibody, CSF2RAX antibody, CSF2RAY antibody, CSF2RX antibody, CSF2RY antibody, GM-CSF-R-alpha antibody, GMCSFR antibody, GMR antibody, SMDP4 antibody, Csfgmra antibody, GM-CSF-Ra antibody, GM-CSFR antibody, colony stimulating factor 2 receptor, alpha antibody, colony stimulating factor 2 receptor alpha subunit antibody, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) antibody, CSF2RA antibody, Csf2ra antibody

Background: CD116 (GM-CSF R alpha) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). CD116 heterodimerizes with CD131, the common beta chain subunit shared with IL-3 and IL5 receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.

UniProt: P15509

Pathways: JAK-STAT Signaling