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anthrax Toxin Receptor 1 (ANTXR1) (AA 501-564) antibody

Details for Product No. ABIN554268
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Antigen
Synonyms ANTXR1, ATR, TEM8, 2310008J16Rik, 2810405N18Rik, Antrx1, Tem8
Epitope
AA 501-564
(16), (15), (8), (6), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(100), (43), (39), (13), (12), (1)
Host
Rabbit
(93), (8), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
ELISA
(56), (40), (24), (24), (19), (13), (11), (4), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN554268
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Immunogen Synthetic peptide contain a sequence corresponding to a region within amino acids 501 and 564 of TEM8
Isotype IgG
Characteristics Cellular Localization: Cell membrane , Cell projection , lamellipodium membrane , filopodium membrane
Purification Purified by antigen-affinity chromatography..
Alternative Name Anthrax toxin receptor 1
Background This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq]
Synonyms: ATR antibody, FLJ10601 antibody, FLJ11298 antibody, FLJ21776 antibody, TEM8 antibody, ANTXR1 antibody, 2810405N18Rik antibody, tumor endothelial marker 8 antibody, anthrax toxin receptor 1 antibody, 2310008J16Rik antibody
Molecular Weight 63 kDa
Research Area Receptors, Toxicology
Comment

Positive Controls: Synthetic peptide: 1:8,000

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Pongubala, Nagulapalli, Klemsz et al.: "PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity." in: Molecular and cellular biology, Vol. 12, Issue 1, pp. 368-78, 1992 (PubMed).

Klemsz, McKercher, Celada et al.: "The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene." in: Cell, Vol. 61, Issue 1, pp. 113-24, 1990 (PubMed).

Moreau-Gachelin, Ray, Mattei et al.: "The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias." in: Oncogene, Vol. 4, Issue 12, pp. 1449-56, 1990 (PubMed).

Shin, Koshland: "Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element." in: Genes & development, Vol. 7, Issue 10, pp. 2006-15, 1993 (PubMed).

Rivera, Stuiver, Steenbergen et al.: "Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression." in: Molecular and cellular biology, Vol. 13, Issue 11, pp. 7163-9, 1993 (PubMed).

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