ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 262-277) antibody

Details for Product No. ABIN5551799, Supplier: Log in to see
Antigen
  • MDR1
  • xemdr
  • ABC20
  • CD243
  • CLCS
  • GP170
  • P-GP
  • PGY1
  • p-gp
  • Abcb1
  • Mdr1a
  • ABCB1
  • PGP1
  • Mdr1
  • Mdr1b
  • Pgy-1
  • Pgy1
  • mdr
  • Mdr
  • Cd243
  • Mdr-1
  • Mod-2
  • Mod-2r
  • Mod-2s
  • Mod2-r
  • Mod2-s
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B
  • malic enzyme complex, mitochondrial
  • ABCB1
  • abcb1
  • Abcb1a
  • Abcb1b
  • Mod2
Epitope
AA 262-277
38
36
13
9
7
4
3
3
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus)
268
27
17
13
10
7
7
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
182
97
Clonality
Polyclonal
Conjugate
Un-conjugated
14
9
9
7
5
5
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
140
82
75
74
37
35
24
23
8
7
6
3
3
2
2
2
1
Options
Supplier
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Immunogen Synthetic peptide corresponding to amino acids 262-277 of Human ABCB1 protein.
Isotype IgG
Specificity This antibody is directed against Human ABCB1 protein.
Cross-Reactivity (Details) Species reactivity (expected):Monkey, Canine, Mouse and Rat.
Species reactivity (tested):Human.
Characteristics Concentration: 1.28 mg/mL (by UV absorbance at 280 nm)
Purification Immunoaffinity Chromatography.
Alternative Name CD243 / MDR1 (ABCB1 Antibody Abstract)
Background ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.Synonyms: ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, PGY1
Gene ID 5243
NCBI Accession NP_000918
UniProt P08183
Application Notes ELISA: 1/10,000-1/50,000. Western Blot: 1/200-1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.28 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to to immediate use.
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