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CrkL antibody (C-Term)

CRKL Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN374141
  • Target See all CrkL (CRKL) Antibodies
    CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
    Binding Specificity
    • 22
    • 19
    • 15
    • 14
    • 12
    • 9
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 97
    • 71
    • 26
    • 5
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 116
    • 8
    • 2
    • 1
    Goat
    Clonality
    • 114
    • 12
    Polyclonal
    Conjugate
    • 45
    • 11
    • 10
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This CrkL antibody is un-conjugated
    Application
    • 77
    • 45
    • 26
    • 26
    • 17
    • 15
    • 13
    • 12
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequence
    C-KIFDPQNPDE NE
    Specificity
    This antibody detects CRLK at C-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide from C Terminus of the protein sequence according to NP_005198.1 Genename: CRKL
    Top Product
    Discover our top product CRKL Primary Antibody
  • Application Notes
    Peptide ELISA: Limit dilution 1: 16000. Western blot: 0.01-0.03 μg/mL. Approx 37 kDa band observed in K562 and Jurkat lysates(calculated MW of 33.7 kDa according to NP_005198).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
    Alternative Name
    CRKL (CRKL Products)
    Synonyms
    CRKL antibody, wu:fa55g05 antibody, wu:fj60e01 antibody, zgc:63469 antibody, 1110025F07Rik antibody, AA589403 antibody, AI325100 antibody, Crkol antibody, CRK like proto-oncogene, adaptor protein antibody, v-crk avian sarcoma virus CT10 oncogene homolog-like antibody, CRKL antibody, crkl antibody, Crkl antibody
    Background
    Crkl is a 33 kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependant manner. Crkl is a substitute of BCR ABL tyrosine kinase. In addition, Crkl has oncogenic potential.Synonyms: Crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like
    Gene ID
    1399
    NCBI Accession
    NP_005198
    UniProt
    P46109
    Pathways
    Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor
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