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TFEB antibody (N-Term)

TFEB Reactivity: Human, Mouse, Rat, Dog, Cow, Pig WB, IHC (p), ChIP, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN374208
  • Target See all TFEB Antibodies
    TFEB (Transcription Factor EB (TFEB))
    Binding Specificity
    • 16
    • 9
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 64
    • 30
    • 26
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Pig
    Host
    • 57
    • 6
    • 1
    Goat
    Clonality
    • 57
    • 6
    Polyclonal
    Conjugate
    • 40
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TFEB antibody is un-conjugated
    Application
    • 58
    • 32
    • 14
    • 13
    • 13
    • 13
    • 10
    • 9
    • 8
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA)
    Sequence
    ASRIGLRMQL MRE-C
    Specificity
    This antibody detects TFEB at N-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat, Canine, Porcine and Bovine.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide from N Terminus of the protein sequence according to NP_009093.1 Genename: TFEB
    Top Product
    Discover our top product TFEB Primary Antibody
  • Application Notes
    Peptide ELISA: Limit dilution 1: 16000. Western blot: 0.5-2 μg/mL. Approx 50-55 kDa band seen in NIH-3T3 lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    TFEB (Transcription Factor EB (TFEB))
    Alternative Name
    TFEB (TFEB Products)
    Synonyms
    TFEB antibody, tcfeb antibody, MGC145796 antibody, alphatfeb antibody, ALPHATFEB antibody, BHLHE35 antibody, TCFEB antibody, Tcfeb antibody, bHLHe35 antibody, transcription factor EB antibody, TFEB antibody, tfeb antibody, Tfeb antibody
    Background
    Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.Synonyms: Transcription factor EB
    Gene ID
    7942
    NCBI Accession
    NP_009093
    UniProt
    P19484
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