SLC12A6 antibody (Internal Region)

Catalog No. ABIN374883

Product Details anti-SLC12A6 Antibody

Target: SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))

Binding Specificity: Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This SLC12A6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: SRHIDVCSKT KE

Specificity: This antibody detects Solute carrier family 12 member 6. It is expected to recognise all 6 reported isofoms (NP_598408.1, NP_005126.1, NP_001035959.1, NP_001035960.1, NP_001035961.1, NP_001035962.1)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from the internal region of the Human SLC12A6 (NP_001035959.1, NP_001035960.1, NP_001035961.1, NP_001035962.1, NP_005126.1, NP_598408.1. Genename: SLC12A6

Application Details

Application Notes: Peptide ELISA: limit dilution 1: 16000. Western blot: 0.1-0.3 μg/mL. Approx 120 kDa band observed in Human Heart and Kidneylysates (calculated MW ranging 121-120 kDa according to NP_598408.1, NP_005126.1,NP_001035959.1, NP_001035960.1, NP_001035961.1, NP_001035962.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SLC12A6

Target: SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))

Alternative Name: SLC12A6 (SLC12A6 Products)

Synonyms: Kcc3 antibody, ACCPN antibody, KCC3 antibody, KCC3A antibody, KCC3B antibody, 9530023I19Rik antibody, gaxp antibody, solute carrier family 12, member 6 antibody, solute carrier family 12 member 6 antibody, Slc12a6 antibody, SLC12A6 antibody

Background: K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The SLC12A6 protein is activated by cell swelling induced by hypotonic conditions. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy (ACCPN). ACCPN is characterised by severe progressive sensorimotor neuropathy, mental retardation, dysmorphic features, and partial or complete agenesis of the corpus callosum. The SLC12Ag gene is a candidate gene for schizophrenia and has also been associated with bipolar disease.Synonyms: Electroneutral, K-Cl cotransporter 3, KCC3, Solute carrier family 12 member 6

Gene ID: 9990

NCBI Accession: NP_001035959

UniProt: Q9UHW9