IDE antibody (Internal Region)

Catalog No. ABIN375106

Product Details anti-IDE Antibody

Target: IDE (Insulin-Degrading Enzyme (IDE))

Binding Specificity: Internal Region

Reactivity: Human, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This IDE antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to Insulysin / Insulinase.

Cross-Reactivity (Details): Species reactivity (expected):Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-QQYNFDRDNTE, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Alternative Name: Insulin-Degrading Enzyme (IDE Products)

Synonyms: zgc:162603 antibody, IDE antibody, 1300012G03Rik antibody, 4833415K22Rik antibody, AA675336 antibody, AI507533 antibody, INSDEGM antibody, INSULYSIN antibody, insulin degrading enzyme antibody, insulin-degrading enzyme antibody, metallopeptidase antibody, IDE antibody, ide antibody, LOC591315 antibody, CC1G_01115 antibody, Bm1_26615 antibody, PTRG_10875 antibody, SJAG_01430 antibody, EBI_21700 antibody, VDBG_06702 antibody, LOAG_08082 antibody, PGTG_04982 antibody, Tsp_00424 antibody, Ide antibody

Background: Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.Synonyms: Abeta-degrading protease, EC=3.4.24.56, IDE, Insulin protease, Insulinase, Insulysin

Gene ID: 3416, 9606

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome