Synaptosomal-Associated Protein, 23kDa (SNAP23) (C-Term) antibody

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Antigen
  • 23kDa
  • AA408749
  • SNAP-23
  • Sndt
  • Syndet
  • HsT17016
  • SNAP23A
  • SNAP23B
  • XOSNAP-23
  • snap23-A
  • synaptosomal-associated protein, 23kDa
  • synaptosomal-associated protein 23
  • SNAP23
  • snap23
  • Snap23
Epitope
C-Term
25
14
10
6
5
4
4
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
118
34
34
5
3
3
1
1
1
1
1
1
Host
Goat
74
31
14
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
96
56
41
26
13
13
10
8
4
2
Options
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Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_003816.2, NP_570710.1. Genename: SNAP23
Sequence C-TDKADTNRDR
Specificity This antibody is expected to recognize both isoforms (NP_003816.2, NP_570710.1). Amino acid numbering in name refers to NP_003816.2 sequence.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Dog, Cow, Rabbit.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name SNAP23 (SNAP23 Antibody Abstract)
Background Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.Synonyms: SNAP-23, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23
Gene ID 8773
NCBI Accession NP_003816
UniProt O00161
Research Area Neurology
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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