TRIM21 antibody (C-Term)

Catalog No. ABIN569661

Product Details anti-TRIM21 Antibody

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TRIM21 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: CPLNIGSQGS TDY

Specificity: Recognizes 52 Kd Ro Protein (TRIM21).

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide (CPLNIGSQGSTDY) from C-terminus of Human TRIM21

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Alternative Name: SS-A / Ro52 / TRIM21 (TRIM21 Products)

Synonyms: RNF81 antibody, RO52 antibody, SSA antibody, SSA1 antibody, Ro52 antibody, Ssa1 antibody, tripartite motif containing 21 antibody, tripartite motif-containing 21 antibody, TRIM21 antibody, Trim21 antibody

Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is part of the RoSSA ribonucleoprotein which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. The function of the RoSSA particle has not been determined. Two alternatively spliced transcript variants for this gene have been described, however, the full length nature of one variant has not been determined.Synonyms: E3 ubiquitin-protein ligase TRIM21, RING finger protein 81, RNF81, Ro(SS-A), SSA1, Sjoegren syndrome type A antigen, TRIM21, Tripartite motif-containing protein 21

Gene ID: 6737

NCBI Accession: NP_003132

UniProt: P19474