ZMIZ1 antibody (N-Term)

Catalog No. ABIN783452

Product Details anti-ZMIZ1 Antibody

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZMIZ1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects ZMIZ1 / RAI17 at N-term. At least three isoforms are known to exist, this antibody will recognize all three. ZIMP10 antibody is predicted to not cross-react with other PIAS protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the amino terminus of human ZIMP10

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZMIZ1

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Alternative Name: ZMIZ1 / RAI17 (ZMIZ1 Products)

Background: ZIMP10, also known as ZMIZ1, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein initially identified as a transcriptional co-activator of the androgen receptor (AR). ZIMP10 and the related protein ZIMP7 interact with PIAS3 and enhances AR-mediated transcription. Later experiments showed that ZIMP10 is also a co-activator of the p53 tumor suppressor. Mice deficient in ZIMP10 result in embryonic lethality by E10.5, these embryos reveal severe defects in the reorganization of the yolk sac vascular plexus, indicating that ZIMP10 plays an important role in proper vascular development.Synonyms: KIAA1224, PIAS-like protein Zimp10, Retinoic acid-induced protein 17, ZIMP10, Zinc finger MIZ domain-containing protein 1

Gene ID: 57178

NCBI Accession: NP_065071

UniProt: Q9ULJ6