LCMT2 antibody (N-Term)

Catalog No. ABIN783492

Product Details anti-LCMT2 Antibody

Target: LCMT2 (Leucine Carboxyl Methyltransferase 2 (LCMT2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCMT2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects LCMT2 at N-term. TYW4 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW4 are known to exist, this antibody will detect only the long isoform.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human TYW4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for LCMT2

Target: LCMT2 (Leucine Carboxyl Methyltransferase 2 (LCMT2))

Alternative Name: LCMT2 (LCMT2 Products)

Synonyms: si:ch211-194d6.3 antibody, wu:fi38a08 antibody, PPM2 antibody, TYW4 antibody, D330024M17 antibody, Tyw4 antibody, leucine carboxyl methyltransferase 2 antibody, hypothetical protein antibody, tRNA methyltransferase antibody, ANI_1_1244164 antibody, AOR_1_496094 antibody, PTRG_08920 antibody, BDBG_01006 antibody, MCYG_03718 antibody, MGYG_03321 antibody, PGTG_17062 antibody, lcmt2 antibody, CAALFM_C101150CA antibody, LCMT2 antibody, Lcmt2 antibody

Background: TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.Synonyms: KIAA0547, Leucine carboxyl methyltransferase 2, TYW4, p21WAF1/CIP1 promoter-interacting protein, tRNA wybutosine-synthesizing protein 4 homolog, tRNA yW-synthesizing protein 4 homolog

Gene ID: 9836

NCBI Accession: NP_055608

UniProt: O60294