PEAR1 antibody (C-Term)

Catalog No. ABIN783779

Product Details anti-PEAR1 Antibody

Target: PEAR1 (Platelet Endothelial Aggregation Receptor 1 (PEAR1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEAR1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PEAR1 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of human PEAR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for PEAR1

Target: PEAR1 (Platelet Endothelial Aggregation Receptor 1 (PEAR1))

Alternative Name: PEAR1 (PEAR1 Products)

Synonyms: MEGF12 antibody, JEDI antibody, 3110045G13Rik antibody, Jedi-1 antibody, Megf12 antibody, RGD1305653 antibody, platelet endothelial aggregation receptor 1 antibody, PEAR1 antibody, pear1 antibody, Pear1 antibody

Background: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated, the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbb3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.Synonyms: MEGF12, Multiple EGF-like domains protein 12, Multiple epidermal growth factor-like domains protein 12, Platelet endothelial aggregation receptor 1

Gene ID: 375033

NCBI Accession: NP_001073940

UniProt: Q5VY43